IL-8 induces neutrophil chemotaxis predominantly via type I IL-8 receptors

M. Elizabeth Hammond, Gena Lapointe, Paul Feucht, +6

The Journal of Immunology

Design, Structure−Activity Relationships and in Vivo Characterization of 4-Amino-3-benzimidazol-2-ylhydroquinolin-2-ones: A Novel Class of Receptor Tyrosine Kinase Inhibitors

Paul A. Renhowe, Sabina Pecchi, Cynthia M. Shafer, +20

Journal of Medicinal Chemistry

Pan-PIM Kinase Inhibition Provides a Novel Therapy for Treating Hematologic Cancers

Pablo D. García, John L. Langowski, Yingyun Wang, +31

Clinical Cancer Research

Discovery of Potent and Selective RSK Inhibitors as Biological Probes

Rama Jain, Michelle Mathur, Jiong Lan, +13

Journal of Medicinal Chemistry

Drug TargetChemoprevention StrategyRsk Kinase FamilyChemical BiologyTumor Biology +15

Identification of <i>N</i>-(4-((1<i>R</i>,3<i>S</i>,5<i>S</i>)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide (PIM447), a Potent and Selective Proviral Insertion Site of Moloney Murine Leukemia (PIM) 1, 2, and 3 Kinase Inhibitor in Clinical Trials for Hematological Malignancies

Matthew T. Burger, Gisele Nishiguchi, Wooseok Han, +29

Journal of Medicinal Chemistry

Hematological MalignancyMoloney Murine LeukemiaMedicinal ChemistryKinase InhibitorMedicine +12

A Genome-wide CRISPR Screen Identifies ZCCHC14 as a Host Factor Required for Hepatitis B Surface Antigen Production

Anastasia Hyrina, Christopher T. Jones, Darlene Chen, +12

Cell Reports

Synthetic VirologyImmunologyMolecular BiologyChronic Hepatitis BHbsag Expression +16

Receptor Recognition and Specificity of Interleukin-8 Is Determined by Residues That Cluster Near a Surface-accessible Hydrophobic Pocket

Mary Ellen Wernette Hammond, Venkatakrishna Shyamala, Michael A. Siani, +8

Journal of Biological Chemistry

Discovery of novel 3,5-disubstituted indole derivatives as potent inhibitors of Pim-1, Pim-2, and Pim-3 protein kinases

Gisele Nishiguchi, Gordana Atallah, Cornelia Bellamacina, +7

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBiochemistryNatural SciencesMedicinePim-3 Protein Kinases +4

Structure Guided Optimization, in Vitro Activity, and in Vivo Activity of Pan-PIM Kinase Inhibitors

Matthew T. Burger, Wooseok Han, Jiong Lan, +21

ACS Medicinal Chemistry Letters

Drug TargetPan-pim Kinase InhibitorsChemical BiologyTumor BiologyMedicinal Chemistry +17

Characterization of the human immunodeficiency virus type-1 reverse transcriptase enzyme produced in yeast

Ian Bathurst, Laura K. Moen, Marc A. Lujan, +6

Biochemical and Biophysical Research Communications

Viral ReplicationNatural SciencesHuman RetrovirusMolecular BiologyVirology +7