A small-molecule P2RX7 activator promotes anti-tumor immune responses and sensitizes lung tumor to immunotherapy

Laëtitia Douguet, Séréna Janho dit Hreich, Jonathan Benzaquen, +17

Nature Communications

Targeting the DNA-binding activity of the human ERG transcription factor using new heterocyclic dithiophene diamidines

Raja Nhili, Paul Peixoto, Sabine Depauw, +11

Nucleic Acids Research

Molecular BiologyChemical BiologyTumor BiologyMedicinal ChemistryMolecular Base +14

GILZ inhibits the mTORC2/AKT pathway in BCR-ABL+ cells

Sami Joha, A-L Nugues, Dominique Hétuin, +8

Oncogene

Pyroglutamide-Based P2X7 Receptor Antagonists Targeting Inflammatory Bowel Disease

Germain Homerin, Samir Jawhara, Xavier Dezitter, +18

Journal of Medicinal Chemistry

Pyrazolones as inhibitors of immune checkpoint blocking the PD-1/PD-L1 interaction

Raphaël Le Biannic, Romain Magnez, Frédérique Klupsch, +11

European Journal of Medicinal Chemistry

Immune CheckpointMedicineImmunologyTumor ImmunityImmune Checkpoint Inhibitor +5

A Structural Explanation of the Effects of Dissociated Glucocorticoids on Glucocorticoid Receptor Transactivation

Xavier Dezitter, Jérôme Fagart, Solenne Taront, +6

Molecular Pharmacology

Enantioseparation of pyroglutamide derivatives on polysaccharide based chiral stationary phases by high-performance liquid chromatography and supercritical fluid chromatography: A comparative study

Davy Baudelet, Nadège Schifano-Faux, Alina Ghinet, +8

Journal of Chromatography A

Pyroglutamide DerivativesEngineeringSupercritical Fluid ChromatographyMedicineChromatographic Analysis +8

ZrCl4 as a new catalyst for ester amidation: an efficient synthesis of h-P2X7R antagonists

Germain Homerin, Davy Baudelet, Pierrick Dufrénoy, +5

Tetrahedron Letters

New CatalystCombinatorial ChemistryMedicinal ChemistryNovel OrganocatalystsEngineering +10

Development of novel oxazolo[5,4-d]pyrimidines as competitive CB2 neutral antagonists based on scaffold hopping

Wei Tuo, Mélanie Bollier, Natascha Leleu‐Chavain, +8

European Journal of Medicinal Chemistry

Combinatorial ChemistryScaffold HoppingBiochemistryMedicinePharmacological Agent +5

Distinctly Different Dynamics and Kinetics of Two Steroid Receptors at the Same Response Elements in Living Cells

Hatice Zeynep Nenseth, Xavier Dezitter, Martina Tesikova, +4

PLoS ONE

Steroid ReceptorsSame Response ElementsGlucocorticoidCellular PhysiologyTranscriptional Regulation +18