IL-2 is inactivated by the acidic pH environment of tumors enabling engineering of a pH-selective mutein

Silvia Gaggero, Jonathan Martínez‐Fábregas, Adeline Cozzani, +18

Science Immunology

PD-1/PD-L1 binding studies using microscale thermophoresis

Romain Magnez, Bryan Thiroux, Solenne Taront, +3

Scientific Reports

Toward the Discovery of a Novel Class of YAP–TEAD Interaction Inhibitors by Virtual Screening Approach Targeting YAP–TEAD Protein–Protein Interface

Floriane Gibault, Mathilde Coevoet, Manon Sturbaut, +14

Cancers

Discovery of a cryptic site at the interface 2 of TEAD – Towards a new family of YAP/TAZ-TEAD inhibitors

Manon Sturbaut, Fabrice Bailly, Mathilde Coevoet, +11

European Journal of Medicinal Chemistry

Molecular PharmacologyNew FamilyPharmaceutical ChemistryDrug TargetBiochemistry +10

Tau Stabilizes Chromatin Compaction

Thomas Rico, Melissa Gilles, Alban Chauderlier, +9

Frontiers in Cell and Developmental Biology

Histone ModificationsEpigenetic ChangeMolecular BiologyEpigeneticsCell Regulation +17

Pyrazolones as inhibitors of immune checkpoint blocking the PD-1/PD-L1 interaction

Raphaël Le Biannic, Romain Magnez, Frédérique Klupsch, +11

European Journal of Medicinal Chemistry

Immune CheckpointMedicineImmunologyTumor ImmunityImmune Checkpoint Inhibitor +5

Slowing down fat digestion and absorption by an oxadiazolone inhibitor targeting selectively gastric lipolysis

Vanessa Point, Anaïs Bénarouche, Julie Zarrillo, +12

European Journal of Medicinal Chemistry

Metabolic SyndromeGastric LipolysisBiochemistryLipid SynthesisGastrointestinal Pharmacology +9

Measurement of Protein-Protein Interactions through Microscale Thermophoresis (MST)

Romain Magnez, Bryan Thiroux, Morgane Tardy, +2

BIO-PROTOCOL

MUC4-ErbB2 Oncogenic Complex: Binding studies using Microscale Thermophoresis

Maxime Liberelle, Romain Magnez, Xavier Thuru, +8

Scientific Reports

Direct interaction of TrkA/CD44v3 is essential for NGF-promoted aggressiveness of breast cancer cells

Sarah Trouvilliez, Julien Cicero, Romain Lévêque, +18

Journal of Experimental & Clinical Cancer Research