Thomas R. Sharpe

Rational Design of Potent, Bioavailable, Nonpeptide Cyclic Ureas as HIV Protease Inhibitors

Patrick Y. S. Lam, Prabhakar K. Jadhav, Charles J. Eyermann et al. · Science · 1994 · 834 citations

Combinatorial Chemistry, Bioorganic Chemistry, Nonpeptide Cyclic Ureas +18

Cyclic HIV Protease Inhibitors:  Synthesis, Conformational Analysis, P2/P2‘ Structure−Activity Relationship, and Molecular Recognition of Cyclic Ureas

Patrick Y. S. Lam, Yu Ru, Prabhakar K. Jadhav et al. · Journal of Medicinal Chemistry · 1996 · 170 citations · Full text

Improved cyclic urea inhibitors of the HIV-1 protease: synthesis, potency, resistance profile, human pharmacokinetics and X-ray crystal structure of DMP 450

C. Nicholas Hodge, Paul E. Aldrich, Lee T. Bacheler et al. · Chemistry & Biology · 1996 · 148 citations · Full text

Hiv-1 Protease, Biochemistry, Medicine +9

Determinants of somatization in primary care

K. Bridges, David Goldberg, Barbara J. Evans et al. · Psychological Medicine · 1991 · 140 citations

Psychotherapy, Family Medicine, Psychological Co-morbidities +21

Patient compliance with antibiotic regimens

Thomas R. Sharpe, Robert L. Mikeal · American Journal of Health-System Pharmacy · 1974 · 90 citations

Family Medicine, Pharmacotherapy, Drug Dispensing +25