Larry M. Tremaine

The Utility of in Vitro Cytochrome P450 Inhibition Data in the Prediction of Drug-Drug Interactions

R. Scott Obach, Robert L. Walsky, Karthik Venkatakrishnan et al. · Journal of Pharmacology and Experimental Therapeutics · 2005 · 434 citations

SERTRALINE IS METABOLIZED BY MULTIPLE CYTOCHROME P450 ENZYMES, MONOAMINE OXIDASES, AND GLUCURONYL TRANSFERASES IN HUMAN: AN IN VITRO STUDY

R. Scott Obach, Loretta M. Cox, Larry M. Tremaine · Drug Metabolism and Disposition · 2004 · 207 citations

Pharmacokinetics of Sertraline and its N-Demethyl Metabolite in Elderly and Young Male and Female Volunteers

Robert A. Ronfeld, Larry M. Tremaine, Keith D. Wilner · Clinical Pharmacokinetics · 1997 · 148 citations

N-demethyl Metabolite, Pharmacological Study, Female Volunteers +7

Deuterium Isotope Effects on Drug Pharmacokinetics. I. System-Dependent Effects of Specific Deuteration with Aldehyde Oxidase Cleared Drugs

Raman Sharma, Timothy J. Strelevitz, Hongying Gao et al. · Drug Metabolism and Disposition · 2011 · 112 citations

A Novel Relay Method for Determining Low-Clearance Values

Li Di, Patrick Trapa, R. Scott Obach et al. · Drug Metabolism and Disposition · 2012 · 108 citations