Fernanda Ortis

Initiation and execution of lipotoxic ER stress in pancreatic β-cells

Daniel A. Cunha, Paul Hekerman, Laurence Ladrière et al. · Journal of Cell Science · 2008 · 584 citations · Full text

Lipid Peroxidation, Apoptosis, Cell Death +23

Cytokines Downregulate the Sarcoendoplasmic Reticulum Pump Ca2+ ATPase 2b and Deplete Endoplasmic Reticulum Ca2+, Leading to Induction of Endoplasmic Reticulum Stress in Pancreatic β-Cells

Alessandra K. Cardozo, Fernanda Ortis, Joachim Størling et al. · Diabetes · 2005 · 513 citations · Full text

The Human Pancreatic Islet Transcriptome: Expression of Candidate Genes for Type 1 Diabetes and the Impact of Pro-Inflammatory Cytokines

Décio L. Eizirik, Michael Sammeth, Thomas Bouckenooghe et al. · PLoS Genetics · 2012 · 472 citations · Full text

Selective Inhibition of Eukaryotic Translation Initiation Factor 2α Dephosphorylation Potentiates Fatty Acid-induced Endoplasmic Reticulum Stress and Causes Pancreatic β-Cell Dysfunction and Apoptosis

Miriam Cnop, Laurence Ladrière, Paul Hekerman et al. · Journal of Biological Chemistry · 2006 · 284 citations · Full text

Palmitate induces a pro-inflammatory response in human pancreatic islets that mimics CCL2 expression by beta cells in type 2 diabetes

Mariana Igoillo‐Esteve, Lorella Marselli, Daniel A. Cunha et al. · Diabetologia · 2010 · 230 citations · Full text

Inflammation, Mimics Ccl2 Expression, Signal Transduction +12