Alejandro Gutiérrez

An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element

Marc R. Mansour, Brian J. Abraham, Lars Anders et al. · Science · 2014 · 797 citations · Full text

Engineering, Mixed-phenotype Acute Leukemia, Genetics +18

SCFFBW7 regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction

Hiroyuki Inuzuka, Shavali Shaik, Ichiro Onoyama et al. · Nature · 2011 · 628 citations · Full text

Signaling Pathway, Cell Regulation, Apoptosis +6

High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemia

Alejandro Gutiérrez, Takaomi Sanda, Ruta Grebliunaite et al. · Blood · 2009 · 436 citations · Full text

An “off-the-shelf” fratricide-resistant CAR-T for the treatment of T cell hematologic malignancies

Matthew Cooper, Jaebok Choi, Karl Staser et al. · Leukemia · 2018 · 381 citations · Full text

Cell Therapy, Hematology, Immunology +5

An epigenetic mechanism of resistance to targeted therapy in T cell acute lymphoblastic leukemia

Birgit Knoechel, Justine E. Roderick, Kaylyn E. Williamson et al. · Nature Genetics · 2014 · 376 citations · Full text

Hematological Malignancy, Chromatin, Mixed-phenotype Acute Leukemia +11