Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion

Robert D. Leone, Liang Zhao, Judson M. Englert, +14

Science

ImmunologyMetabolic RemodelingImmunotherapyCancer BiologyTumor Biology +14

Targeting glutamine metabolism enhances tumor-specific immunity by modulating suppressive myeloid cells

Min Hee Oh, Im‐Hong Sun, Liang Zhao, +17

Journal of Clinical Investigation

ImmunologyImmunoeditingImmunotherapyCancer BiologyTumor Biology +15

mTORC1 and mTORC2 selectively regulate CD8+ T cell differentiation

Kristen Pollizzi, Chirag H. Patel, Im‐Hong Sun, +5

Journal of Clinical Investigation

Immunological MemoryMtor Complex 1Signal TransductionLymphocyte DevelopmentMedicine +10

Asymmetric inheritance of mTORC1 kinase activity during division dictates CD8+ T cell differentiation

Kristen Pollizzi, Im‐Hong Sun, Chirag H. Patel, +8

Nature Immunology

Signal TransductionSignaling PathwayCell DivisionAsymmetric InheritanceCell Regulation +8

The AGC kinase SGK1 regulates TH1 and TH2 differentiation downstream of the mTORC2 complex

Emily Heikamp, Chirag H. Patel, Sam Collins, +10

Nature Immunology

Signal TransductionSignaling PathwayCell RegulationMolecular RegulationNutrient Signalling +8

Inhibition of the adenosine A2a receptor modulates expression of T cell coinhibitory receptors and improves effector function for enhanced checkpoint blockade and ACT in murine cancer models

Robert D. Leone, Im-Meng Sun, Min Hee Oh, +4

Cancer Immunology Immunotherapy

Cancer ImmunosurveillanceMurine Cancer ModelsImmunologyImmune Checkpoint InhibitorEnhanced Checkpoint Blockade +6

mTOR Complex 1 Signaling Regulates the Generation and Function of Central and Effector Foxp3+ Regulatory T Cells

Im‐Hong Sun, Min Hee Oh, Liang Zhao, +7

The Journal of Immunology

Metabolic programs define dysfunctional immune responses in severe COVID-19 patients

Elizabeth A. Thompson, Katherine Cascino, Alvaro A. Ordoñez, +23

Cell Reports

Elderly PatientsT-regulatory CellImmunologyImmunologic MechanismT Cells +16

Flagella stator homologs function as motors for myxobacterial gliding motility by moving in helical trajectories

Beiyan Nan, Jigar N. Bandaria, Amirpasha Moghtaderi, +2

Proceedings of the National Academy of Sciences

A multi-protein complex from Myxococcus xanthus required for bacterial gliding motility

Beiyan Nan, Emilia M. F. Mauriello, Im‐Hong Sun, +2

Molecular Microbiology