Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion

Robert D. Leone, Liang Zhao, Judson M. Englert, +14

Science

ImmunologyMetabolic RemodelingImmunotherapyCancer BiologyTumor Biology +14

Developing a pro-regenerative biomaterial scaffold microenvironment requires T helper 2 cells

Kaitlyn Sadtler, Kenneth Estrellas, Brian W. Allen, +11

Science

Tissue EngineeringEngineeringMultifunctional BiomaterialsAdaptive Immune SystemImmunology +19

Targeting glutamine metabolism enhances tumor-specific immunity by modulating suppressive myeloid cells

Min Hee Oh, Im‐Hong Sun, Liang Zhao, +17

Journal of Clinical Investigation

ImmunologyImmunoeditingImmunotherapyCancer BiologyTumor Biology +15

mTORC1 and mTORC2 selectively regulate CD8+ T cell differentiation

Kristen Pollizzi, Chirag H. Patel, Im‐Hong Sun, +5

Journal of Clinical Investigation

Immunological MemoryMtor Complex 1Signal TransductionLymphocyte DevelopmentMedicine +10

Asymmetric inheritance of mTORC1 kinase activity during division dictates CD8+ T cell differentiation

Kristen Pollizzi, Im‐Hong Sun, Chirag H. Patel, +8

Nature Immunology

Signal TransductionSignaling PathwayCell DivisionAsymmetric InheritanceCell Regulation +8

Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR

Zandra E. Walton, Chirag H. Patel, Rebekah Brooks, +15

Cell

SleepChronobiologyBiochemistryPhysiological RegulationMedicine +9

The AGC kinase SGK1 regulates TH1 and TH2 differentiation downstream of the mTORC2 complex

Emily Heikamp, Chirag H. Patel, Sam Collins, +10

Nature Immunology

Signal TransductionSignaling PathwayCell RegulationMolecular RegulationNutrient Signalling +8

The PTPN2/PTPN1 inhibitor ABBV-CLS-484 unleashes potent anti-tumour immunity

Christina K. Baumgartner, Hakimeh Ebrahimi-Nik, Arvin Iracheta‐Vellve, +63

Nature

mTOR Complex 1 Signaling Regulates the Generation and Function of Central and Effector Foxp3+ Regulatory T Cells

Im‐Hong Sun, Min Hee Oh, Liang Zhao, +7

The Journal of Immunology

PKG1-modified TSC2 regulates mTORC1 activity to counter adverse cardiac stress

Mark J. Ranek, Kristen M. Kokkonen-Simon, Anna Chen, +13

Nature

Cardiac MuscleCardiomyopathyMolecular PhysiologySignal TransductionMedicine +6