Reprogramming to recover youthful epigenetic information and restore vision

Yuancheng Ryan Lu, Benedikt Brommer, Xiao Tian, +26

Nature

ChromatinMedicineGeneticsYouthful Epigenetic InformationEpigenetic Change +4

Local fitness landscape of the green fluorescent protein

Karen S. Sarkisyan, Dmitriy A. Bolotin, Margarita Meer, +16

Nature

Protein FunctionProtein AssemblyProtein FoldingNatural SciencesProtein Evolution +3

Loss of epigenetic information as a cause of mammalian aging

Jae-Hyun Yang, Motoshi Hayano, Patrick Griffin, +61

Cell

ChromatinDevelopmental BiologyAgingLongevityGenetics +6

LINE1 Derepression in Aged Wild-Type and SIRT6-Deficient Mice Drives Inflammation

Matthew Simon, Michael Van Meter, Julia Ablaeva, +17

Cell Metabolism

InflammationLifespan ExtensionAutoimmune DiseaseImmune Cell DevelopmentImmunology +9

A whole lifespan mouse multi-tissue DNA methylation clock

Margarita Meer, Dmitriy I. Podolskiy, Alexander Tyshkovskiy, +1

eLife

Anti-agingAgingEpigenetic ChangeGeneticsDna Methylation +14

Compensatory evolution in mitochondrial tRNAs navigates valleys of low fitness

Margarita Meer, Alexey S. Kondrashov, Yael Artzy‐Randrup, +1

Nature

BiologyPhylogeneticsFitnessMitochondrial FunctionNatural Sciences +10

Epigenetic aging of the demographically non-aging naked mole-rat

Csaba Kerepesi, Margarita Meer, Julia Ablaeva, +13

Nature Communications

A rat epigenetic clock recapitulates phenotypic aging and co-localizes with heterochromatin

Morgan E. Levine, Ross A. McDevitt, Margarita Meer, +10

eLife

Loss of Epigenetic Information as a Cause of Mammalian Aging

Jae-Hyun Yang, Motoshi Hayano, Patrick Griffin, +57

SSRN Electronic Journal

ChromatinDevelopmental BiologyAgingLongevityGenetics +6

Systems Age: A single blood methylation test to quantify aging heterogeneity across 11 physiological systems

Raghav Sehgal, Yaroslav Markov, Chenxi Qin, +12

AgingAging ProcessGeriatricsLongevityPhysiological Systems +13