Krishnapriya Chinnaswamy

A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo

Longchuan Bai, Haibin Zhou, Renqi Xu et al. · Cancer Cell · 2019 · 618 citations · Full text

Medicine, Molecular Biology, Oncology +7

Discovery of ARD-69 as a Highly Potent Proteolysis Targeting Chimera (PROTAC) Degrader of Androgen Receptor (AR) for the Treatment of Prostate Cancer

Xin Han, Chao Wang, Chong Qin et al. · Journal of Medicinal Chemistry · 2019 · 381 citations · Full text

Medicine, Oncology, Pharmacology +17

Discovery of ERD-308 as a Highly Potent Proteolysis Targeting Chimera (PROTAC) Degrader of Estrogen Receptor (ER)

Jiantao Hu, Biao Hu, Mingliang Wang et al. · Journal of Medicinal Chemistry · 2019 · 271 citations

Life Sciences, Medicinal Chemistry, Oncology +13

Structure-Based Discovery of SD-36 as a Potent, Selective, and Efficacious PROTAC Degrader of STAT3 Protein

Haibin Zhou, Longchuan Bai, Renqi Xu et al. · Journal of Medicinal Chemistry · 2019 · 213 citations · Full text

Life Sciences, Medicinal Chemistry, Molecular Biology +12

Discovery of Highly Potent and Efficient PROTAC Degraders of Androgen Receptor (AR) by Employing Weak Binding Affinity VHL E3 Ligase Ligands

Xin Han, Lijie Zhao, Weiguo Xiang et al. · Journal of Medicinal Chemistry · 2019 · 212 citations · Full text

Medicine, Oncology, Pharmacology +15