Weiguo Xiang

Discovery of ARD-69 as a Highly Potent Proteolysis Targeting Chimera (PROTAC) Degrader of Androgen Receptor (AR) for the Treatment of Prostate Cancer

Xin Han, Chao Wang, Chong Qin et al. · Journal of Medicinal Chemistry · 2019 · 381 citations · Full text

Medicine, Oncology, Pharmacology +17

Discovery of QCA570 as an Exceptionally Potent and Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of the Bromodomain and Extra-Terminal (BET) Proteins Capable of Inducing Complete and Durable Tumor Regression

Chong Qin, Yang Hu, Bing Zhou et al. · Journal of Medicinal Chemistry · 2018 · 263 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +12

Discovery of Highly Potent and Efficient PROTAC Degraders of Androgen Receptor (AR) by Employing Weak Binding Affinity VHL E3 Ligase Ligands

Xin Han, Lijie Zhao, Weiguo Xiang et al. · Journal of Medicinal Chemistry · 2019 · 212 citations · Full text

Medicine, Oncology, Pharmacology +15

Discovery of ARD-2585 as an Exceptionally Potent and Orally Active PROTAC Degrader of Androgen Receptor for the Treatment of Advanced Prostate Cancer

Weiguo Xiang, Lijie Zhao, Xin Han et al. · Journal of Medicinal Chemistry · 2021 · 140 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Strategies toward Discovery of Potent and Orally Bioavailable Proteolysis Targeting Chimera Degraders of Androgen Receptor for the Treatment of Prostate Cancer

Xin Han, Lijie Zhao, Weiguo Xiang et al. · Journal of Medicinal Chemistry · 2021 · 137 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15