Discovery of the First <i>C</i>-Nucleoside HCV Polymerase Inhibitor (GS-6620) with Demonstrated Antiviral Response in HCV Infected Patients

Aesop Cho, Lijun Zhang, Jie Xu, +21

Journal of Medicinal Chemistry

Viral Polymerase StructureAdenosine AnalogsHepatitis C VirusImmunologyPharmacotherapy +15

Prodrugs of a 1′-CN-4-Aza-7,9-dideazaadenosine <i>C</i>-Nucleoside Leading to the Discovery of Remdesivir (GS-5734) as a Potent Inhibitor of Respiratory Syncytial Virus with Efficacy in the African Green Monkey Model of RSV

Richard L. Mackman, Hon C. Hui, Michel Perron, +28

Journal of Medicinal Chemistry

The Chemokine CCL3 Regulates Myeloid Differentiation and Hematopoietic Stem Cell Numbers

Rhonda J. Staversky, Daniel Byun, Mary Georger, +5

Scientific Reports

Preclinical Characterization of GS-9669, a Thumb Site II Inhibitor of the Hepatitis C Virus NS5B Polymerase

Martijn Fenaux, Stacey Eng, Stephanie A. Leavitt, +24

Antimicrobial Agents and Chemotherapy

Discovery of GS-9669, a Thumb Site II Non-Nucleoside Inhibitor of NS5B for the Treatment of Genotype 1 Chronic Hepatitis C Infection

Scott E. Lazerwith, Willard Lew, Jennifer Zhang, +24

Journal of Medicinal Chemistry

Drug TargetAntiviral DrugChemical BiologyPharmaceutical ChemistryClinical Candidate Gs-9669 +15

A facile reduction of 2-aminopyrimidines with triethylsilane and trifluoroacetic acid

Subramanian Baskaran, Emily J. Hanan, Daniel Byun, +1

Tetrahedron Letters

Bioorganic ChemistryBiochemistryNatural SciencesFacile ReductionOrganic Chemistry +4

Discovery of β-d-2′-deoxy-2′-α-fluoro-4′-α-cyano-5-aza-7,9-dideaza adenosine as a potent nucleoside inhibitor of respiratory syncytial virus with excellent selectivity over mitochondrial RNA and DNA polymerases

Michael O. Clarke, Richard L. Mackman, Daniel Byun, +12

Bioorganic & Medicinal Chemistry Letters

Viral ReplicationNucleic Acid ChemistryBiochemistryNatural SciencesMedicine +11

Chronic Stress Exposure Suppresses Mammary Tumor Growth and Reduces Circulating Exosome TGF-β Content via β-Adrenergic Receptor Signaling in MMTV-PyMT Mice

Ryan P. Dawes, Kathleen A. Burke, Daniel Byun, +5

Breast Cancer Basic and Clinical Research

Breast OncologyImmunologyPathologyCancer BiologyMammary Gland Development +16

Chemotherapeutic drug-specific alteration of microvascular blood flow in murine breast cancer as measured by diffuse correlation spectroscopy

Gabriel Ramirez, Ashley R. Proctor, Ki Won Jung, +11

Biomedical Optics Express

Reduction of leukemic burden via bone‐targeted nanoparticle delivery of an inhibitor of C‐chemokine (C‐C motif) ligand 3 (CCL3) signaling

Marian A. Ackun‐Farmmer, Celia A. Soto, Maggie L. Lesch, +5

The FASEB Journal

Nanoparticle DeliveryImmunologyLeukemia CellsImmunotherapyCancer Biology +21