Roddy S. O’Connor

Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia

Joseph A. Fraietta, Simon F. Lacey, Elena J. Orlando et al. · Nature Medicine · 2018 · 1.7K citations · Full text

T Cell Therapy, Cancer Immunosurveillance, Chronic Lymphocytic Leukemia +6

Human chimeric antigen receptor macrophages for cancer immunotherapy

Michael Klichinsky, Marco Ruella, Olga Shestova et al. · Nature Biotechnology · 2020 · 1.3K citations · Full text

Cancer Immunosurveillance, Immunology, Tumor Immunity +4

Distinct Signaling of Coreceptors Regulates Specific Metabolism Pathways and Impacts Memory Development in CAR T Cells

Omkar U. Kawalekar, Roddy S. O’Connor, Joseph A. Fraietta et al. · Immunity · 2016 · 1.1K citations · Full text

Car T Cells, Molecular Physiology, Signal Transduction +14

Targeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis

Yan Xiang, Zachary E. Stine, Jinsong Xia et al. · Journal of Clinical Investigation · 2015 · 390 citations · Full text

Chemoprevention Strategy, Immunology, Gls Inhibitors +16

Substrate Rigidity Regulates Human T Cell Activation and Proliferation

Roddy S. O’Connor, Xueli Hao, K. Robert Shen et al. · The Journal of Immunology · 2012 · 317 citations · Full text