Human chimeric antigen receptor macrophages for cancer immunotherapy

Michael Klichinsky, Marco Ruella, Olga Shestova, +23

Nature Biotechnology

Cancer ImmunosurveillanceImmunologyTumor ImmunityImmune Checkpoint InhibitorImmunotherapy +2

Induction of resistance to chimeric antigen receptor T cell therapy by transduction of a single leukemic B cell

Marco Ruella, Jun Xu, David M. Barrett, +23

Nature Medicine

Autoimmune DiseaseImmunologyAntigen ProcessingAutoimmunityAdult T-cell Leukemia-lymphoma +3

Dual CD19 and CD123 targeting prevents antigen-loss relapses after CD19-directed immunotherapies

Marco Ruella, David M. Barrett, Saad S. Kenderian, +18

Journal of Clinical Investigation

Mixed-phenotype Acute LeukemiaImmunologyImmunoeditingImmunotherapeuticsImmunotherapy +20

Genetic Inactivation of CD33 in Hematopoietic Stem Cells to Enable CAR T Cell Immunotherapy for Acute Myeloid Leukemia

Miriam Kim, Kyung–Rok Yu, Saad S. Kenderian, +22

Cell

Cell TherapyAcute Myeloid LeukemiaImmunologyHematologyAutoimmunity +7

CD33-specific chimeric antigen receptor T cells exhibit potent preclinical activity against human acute myeloid leukemia

Saad S. Kenderian, Marco Ruella, Olga Shestova, +9

Leukemia

Autoimmune DiseaseT-regulatory CellImmunologyHematologyPotent Preclinical Activity +5

An Atlas of the Epstein-Barr Virus Transcriptome and Epigenome Reveals Host-Virus Regulatory Interactions

Aaron Arvey, Italo Tempera, Kevin Tsai, +5

Cell Host & Microbe

Systems BiologyMolecular VirologyImmunologyEpstein-barr Virus TranscriptomeVirology +6

Overcoming the Immunosuppressive Tumor Microenvironment of Hodgkin Lymphoma Using Chimeric Antigen Receptor T Cells

Marco Ruella, Michael Klichinsky, Saad S. Kenderian, +7

Cancer Discovery

The Addition of the BTK Inhibitor Ibrutinib to Anti-CD19 Chimeric Antigen Receptor T Cells (CART19) Improves Responses against Mantle Cell Lymphoma

Marco Ruella, Saad S. Kenderian, Olga Shestova, +16

Clinical Cancer Research

EBV Latency Types Adopt Alternative Chromatin Conformations

Italo Tempera, Michael Klichinsky, Paul M. Lieberman

PLoS Pathogens

Viral ReplicationMolecular BiologyEpigeneticsEpstein-barr VirusVirus Gene +15

CAR-macrophage therapy for HER2-overexpressing advanced solid tumors: a phase 1 trial

Kim A. Reiss, Mathew G. Angelos, E. Claire Dees, +25

Nature Medicine

Solid TumorsCar-macrophage TherapyMedicineImmunologyBreast Cancer +5