Structure-Based Design and Discovery of Protein Tyrosine Phosphatase Inhibitors Incorporating Novel Isothiazolidinone Heterocyclic Phosphotyrosine Mimetics

Andrew P. Combs, Eddy W. Yue, Michael J. Bower, +30

Journal of Medicinal Chemistry

Molecular DockingCrystal StructureMedicinal ChemistryCombinatorial ChemistryBiochemistry +11

Potent Benzimidazole Sulfonamide Protein Tyrosine Phosphatase 1B Inhibitors Containing the Heterocyclic ( <i>S</i> )-Isothiazolidinone Phosphotyrosine Mimetic

Andrew P. Combs, Wenyu Zhu, Matthew L. Crawley, +24

Journal of Medicinal Chemistry

Structural Insights into the Design of Nonpeptidic Isothiazolidinone-containing Inhibitors of Protein-tyrosine Phosphatase 1B

J. Paul, Lucie Gonneville, Milton C. Hillman, +14

Journal of Biological Chemistry

Phenyl Shifts in Substituted Arenes via <i>Ipso</i> Arenium Ions

Aida Ajaz, Erin McLaughlin, Sarah L. Skraba, +2

The Journal of Organic Chemistry

EngineeringAlkene MetathesisPhenyl ShiftsOrganic ChemistryConstitutional Isomers +7

Benzothiazole benzimidazole (S)-isothiazolidinone derivatives as protein tyrosine phosphatase-1B inhibitors

Richard Sparks, Padmaja Polam, Wenyu Zhu, +12

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBiochemistryBenzothiazole BenzimidazoleMedicineNatural Sciences +6

Scholl Cyclizations of Aryl Naphthalenes: Rearrangement Precedes Cyclization

Sarah L. Skraba-Joiner, Erin McLaughlin, Aida Ajaz, +2

The Journal of Organic Chemistry

Chemical EngineeringAlcl3-catalyzed CyclizationEngineeringHeterocyclicAlkene Metathesis +8

Isothiazolidinone heterocycles as inhibitors of protein tyrosine phosphatases: Synthesis and structure–activity relationships of a peptide scaffold

Eddy W. Yue, Brian Wayland, Brent Douty, +13

Bioorganic & Medicinal Chemistry

BiochemistryMedicinePeptide ScaffoldIsothiazolidinone HeterocyclesPeptide Synthesis +4

CC chemokine receptor-3 (CCR3) antagonists: Improving the selectivity of DPC168 by reducing central ring lipophilicity

James R. Pruitt, Douglas G. Batt, Dean A. Wacker, +22

Bioorganic & Medicinal Chemistry Letters

InflammationCentral Ring LipophilicityBiochemistryCc Chemokine Receptor-3Medicine +4

Concise Approach to Novel Isothiazolidinone Phosphotyrosine Mimetics:  Microwave-Assisted Addition of Bisulfite to Activated Olefins

Matthew L. Crawley, Erin McLaughlin, Wenyu Zhu, +1

Organic Letters

Chemical EngineeringDiversity Oriented SynthesisEngineeringBiochemistryNatural Sciences +12