Development of an in-vivo active reversible butyrylcholinesterase inhibitor

Urban Košak, Boris Brus, Damijan Knez, +22

Scientific Reports

The Magic of Crystal Structure-Based Inhibitor Optimization: Development of a Butyrylcholinesterase Inhibitor with Picomolar Affinity and in Vivo Activity

Urban Košak, Boris Brus, Damijan Knez, +15

Journal of Medicinal Chemistry

Combinatorial ChemistryScopolamine ModelNeurochemical BiomarkersChemical BiologyPharmaceutical Chemistry +21

Multi-target-directed ligands for treating Alzheimer's disease: Butyrylcholinesterase inhibitors displaying antioxidant and neuroprotective activities

Damijan Knez, Nicolas Coquelle, Anja Pišlar, +9

European Journal of Medicinal Chemistry

Alzheimer's DiseaseBiochemistryButyrylcholinesterase InhibitorsMedicineNeuroprotective Activities +7

Determination of permeability coefficients of ophthalmic drugs through different layers of porcine, rabbit and bovine eyes

Christian Loch, Simon Žakelj, Albin Kristl, +4

European Journal of Pharmaceutical Sciences

Animal PhysiologyOphthalmologyExperimental OphthalmologyMedicinePhysiology +11

The effect of lipid composition and liposome size on the release properties of liposomes-in-hydrogel

Julia Hurler, Simon Žakelj, Janez Mravljak, +4

International Journal of Pharmaceutics

Biopolymer GelNanomedicineLipid PreparationLiposome SizeRelease Properties +5

N-alkylpiperidine carbamates as potential anti-Alzheimer’s agents

Urban Košak, Nika Strašek, Damijan Knez, +8

European Journal of Medicinal Chemistry

Alzheimer's DiseaseN-alkylpiperidine CarbamatesMedicinePharmacological AgentNeuropharmacology +3

Ciprofloxacin permeability and its active secretion through rat small intestine in vitro

Simon Žakelj, Katja Šturm, Albin Kristl

International Journal of Pharmaceutics

InflammationGastrointestinal PharmacologyMedicinePhysiologyGastroenterology +6

Fluorescein transport properties across artificial lipid membranes, Caco-2 cell monolayers and rat jejunum

Katja Berginc, Simon Žakelj, Lea Levstik, +2

European Journal of Pharmaceutics and Biopharmaceutics

Rat JejunumProteinlipid InteractionBiochemistryMembrane TransportArtificial Lipid Membranes +7

Stereoselective Activity of 1-Propargyl-4-styrylpiperidine-like Analogues That Can Discriminate between Monoamine Oxidase Isoforms A and B

Damijan Knez, Natalia Colettis, L.G. Iacovino, +14

Journal of Medicinal Chemistry

Suitability of RPMI 2650 cell models for nasal drug permeability prediction

Nadica Sibinovska, Simon Žakelj, Katja Kristan

European Journal of Pharmaceutics and Biopharmaceutics

AllergyMedicineCell ModelsBiomedical ModelingPharmacology +5