<i>TARDBP</i> mutations in motoneuron disease with frontotemporal lobar degeneration

Lina Benajiba, Isabelle Le Ber, Agnès Camuzat, +15

Annals of Neurology

Corticobasal DegenerationGeneticsTardbp MutationsSocial SciencesNeurobiology Of Disease +16

The creatine kinase pathway is a metabolic vulnerability in EVI1-positive acute myeloid leukemia

Nina Fenouille, Christopher F. Bassil, Issam Ben‐Sahra, +18

Nature Medicine

Hematological MalignancySignal TransductionBiochemistryMixed-phenotype Acute LeukemiaAutophagy +8

Addition of iptacopan, an oral factor B inhibitor, to eculizumab in patients with paroxysmal nocturnal haemoglobinuria and active haemolysis: an open-label, single-arm, phase 2, proof-of-concept trial

Antonio M. Risitano, Alexander Röth, Juliette Soret, +12

The Lancet Haematology

ThrombosisHematologyPharmacologyActive HaemolysisHemostasis +5

Exploiting an Asp-Glu “switch” in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia

Florence F. Wagner, Lina Benajiba, Arthur J. Campbell, +27

Science Translational Medicine

High mortality rate in COVID-19 patients with myeloproliferative neoplasms after abrupt withdrawal of ruxolitinib

Tiziano Barbui, Alessandro M. Vannucchi, Alberto Álvarez‐Larrán, +48

Leukemia

Rare melanocortin-3 receptor mutations with in vitro functional consequences are associated with human obesity

Monica Mencarelli, Béatrice Dubern, Rohia Alili, +11

Human Molecular Genetics

Genomic landscape of MDS/CMML associated with systemic inflammatory and autoimmune disease

Lin‐Pierre Zhao, Maxime Boy, Célia Azoulay, +17

Leukemia

InflammationImmunogeneticsAutoimmune DiseaseGenomic LandscapeMedicine +10

Targeting acute myeloid leukemia dependency on VCP-mediated DNA repair through a selective second-generation small-molecule inhibitor

Blandine Roux, Camille Vaganay, Jesse D. Vargas, +33

Science Translational Medicine

P2RY2-AKT activation is a therapeutically actionable consequence of XPO1 inhibition in acute myeloid leukemia

Kevin Lin, Justine C. Rutter, Abigail Xie, +30

Nature Cancer

Hematological MalignancyMedicineAcute Myeloid LeukemiaMixed-phenotype Acute LeukemiaMalignant Blood Disorder +7

Impact of NFE2 mutations on AML transformation and overall survival in patients with myeloproliferative neoplasms

Clémence Marcault, Lin‐Pierre Zhao, Nabih Maslah, +17

Blood