mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle

Issam Ben‐Sahra, Gerta Hoxhaj, Stéphane J. H. Ricoult, +2

Science

Stimulation of de Novo Pyrimidine Synthesis by Growth Signaling Through mTOR and S6K1

Issam Ben‐Sahra, Jessica J. Howell, John M. Asara, +1

Science

The TSC-mTOR pathway regulates macrophage polarization

Vanessa Byles, Anthony J. Covarrubias, Issam Ben‐Sahra, +4

Nature Communications

Signal TransductionSignaling PathwayCell SignalingMacrophage PolarizationMedicine +5

Efferocytosis Fuels Requirements of Fatty Acid Oxidation and the Electron Transport Chain to Polarize Macrophages for Tissue Repair

Shuang Zhang, Samuel E. Weinberg, Matthew DeBerge, +9

Cell Metabolism

InflammationBiochemistryBioenergeticsLipid PeroxidationPhysiology +11

Akt-mTORC1 signaling regulates Acly to integrate metabolic input to control of macrophage activation

Anthony J. Covarrubias, Halil‐Ibrahim Aksoylar, Jiujiu Yu, +13

eLife

Macrophage ActivationImmunologyMetabolic RemodelingCellular PhysiologyInflammation +22

Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages

Anthony J. Covarrubias, Abhijit Kale, Rosalba Perrone, +28

Nature Metabolism

InflammationCd38+ MacrophagesAgingTissue Nad+ DeclineImmunology +9

Amino Acid Restriction Triggers Angiogenesis via GCN2/ATF4 Regulation of VEGF and H2S Production

Alban Longchamp, Teodelinda Mirabella, Alessandro Arduini, +21

Cell

AngiogenesisDevelopmental BiologyNatural SciencesEndothelial DysfunctionVascular Biology +7

Oncogenic PI3K and K-Ras stimulate de novo lipid synthesis through mTORC1 and SREBP

Stéphane J. H. Ricoult, Jessica L. Yecies, Issam Ben‐Sahra, +1

Oncogene

Signal TransductionSignaling PathwayBiochemistryK-ras StimulateNatural Sciences +7

Hypoxia Decreases Insulin Signaling Pathways in Adipocytes

Claire Regazzetti, Pascal Peraldi, Thierry Grémeaux, +7

Diabetes

The mTORC1 Signaling Network Senses Changes in Cellular Purine Nucleotide Levels

Gerta Hoxhaj, James Hughes-Hallett, Rebecca C. Timson, +5

Cell Reports