Issam Ben‐Sahra

mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle

Issam Ben‐Sahra, Gerta Hoxhaj, Stéphane J. H. Ricoult et al. · Science · 2016 · 772 citations

Stimulation of de Novo Pyrimidine Synthesis by Growth Signaling Through mTOR and S6K1

Issam Ben‐Sahra, Jessica J. Howell, John M. Asara et al. · Science · 2013 · 714 citations

The TSC-mTOR pathway regulates macrophage polarization

Vanessa Byles, Anthony J. Covarrubias, Issam Ben‐Sahra et al. · Nature Communications · 2013 · 608 citations · Full text

Signal Transduction, Signaling Pathway, Cell Signaling +7

Efferocytosis Fuels Requirements of Fatty Acid Oxidation and the Electron Transport Chain to Polarize Macrophages for Tissue Repair

Shuang Zhang, Samuel E. Weinberg, Matthew DeBerge et al. · Cell Metabolism · 2018 · 433 citations · Full text

Inflammation, Biochemistry, Bioenergetics +13

Akt-mTORC1 signaling regulates Acly to integrate metabolic input to control of macrophage activation

Anthony J. Covarrubias, Halil‐Ibrahim Aksoylar, Jiujiu Yu et al. · eLife · 2016 · 421 citations · Full text

Macrophage Activation, Immunology, Metabolic Remodeling +24