Carole Shardlow

IMI – Oral biopharmaceutics tools project – Evaluation of bottom-up PBPK prediction success part 2: An introduction to the simulation exercise and overview of results

Alison Margolskee, Adam S. Darwich, Xavier Pépin et al. · European Journal of Pharmaceutical Sciences · 2016 · 66 citations · Full text

Pharmacokinetic Modeling, Medicine, Process Analytical Technology +6

Pharmacokinetics of the novel, high-affinity and selective dopamine D3 receptor antagonist SB-277011 in rat, dog and monkey:<i>in vitro/in vivo</i>correlation and the role of aldehyde oxidase

Nigel Austin, S. J. Baldwin, Leanne Cutler et al. · Xenobiotica · 2001 · 63 citations

IMI – Oral biopharmaceutics tools project – Evaluation of bottom-up PBPK prediction success part 3: Identifying gaps in system parameters by analysing In Silico performance across different compound classes

Adam S. Darwich, Alison Margolskee, Xavier Pépin et al. · European Journal of Pharmaceutical Sciences · 2016 · 45 citations · Full text

Systems Pharmacology, Silico Performance, Pharmacokinetic Modeling +13

Impact of Physiologically Based Pharmacokinetic Modeling and Simulation in Drug Development

Carole Shardlow, Grant T. Generaux, Aarti Patel et al. · Drug Metabolism and Disposition · 2013 · 40 citations

Coformulation of a Novel Human α -Galactosidase A With the Pharmacological Chaperone AT1001 Leads to Improved Substrate Reduction in Fabry Mice

Su Xu, Yi Lun, Nastry Brignol et al. · Molecular Therapy · 2015 · 36 citations · Full text