Carole Shardlow

IMI – Oral biopharmaceutics tools project – Evaluation of bottom-up PBPK prediction success part 2: An introduction to the simulation exercise and overview of results

Alison Margolskee, Adam S. Darwich, Xavier Pépin et al. · European Journal of Pharmaceutical Sciences · 2016 · 67 citations · Full text

Pharmacy, Pharmacokinetics, Pharmacology +16

Pharmacokinetics of the novel, high-affinity and selective dopamine D3 receptor antagonist SB-277011 in rat, dog and monkey:<i>in vitro/in vivo</i>correlation and the role of aldehyde oxidase

Nigel Austin, S. J. Baldwin, Leanne Cutler et al. · Xenobiotica · 2001 · 63 citations

Medicine, Pharmacokinetics, Pharmacology +15

IMI – Oral biopharmaceutics tools project – Evaluation of bottom-up PBPK prediction success part 3: Identifying gaps in system parameters by analysing In Silico performance across different compound classes

Adam S. Darwich, Alison Margolskee, Xavier Pépin et al. · European Journal of Pharmaceutical Sciences · 2016 · 45 citations · Full text

Pharmacy, Pharmacokinetics, Pharmacology +17

Impact of Physiologically Based Pharmacokinetic Modeling and Simulation in Drug Development

Carole Shardlow, Grant T. Generaux, Aarti Patel et al. · Drug Metabolism and Disposition · 2013 · 40 citations

Pharmacy, Pharmacokinetics, Pharmacology +15

Coformulation of a Novel Human α -Galactosidase A With the Pharmacological Chaperone AT1001 Leads to Improved Substrate Reduction in Fabry Mice

Su Xu, Yi Lun, Nastry Brignol et al. · Molecular Therapy · 2015 · 37 citations · Full text

Life Sciences, Biochemistry, Pharmacology +15