Leanne Cutler

Discovery of Epigenetic Regulator I-BET762: Lead Optimization to Afford a Clinical Candidate Inhibitor of the BET Bromodomains

Olivier Mirguet, Romain Gosmini, Jérôme Toum et al. · Journal of Medicinal Chemistry · 2013 · 301 citations · Full text

Histone Modifications, Chemoprevention Strategy, Epigenetic Change +22

Orexin-A, an hypothalamic peptide with analgesic properties

Sharon Bingham, Philip T. Davey, Adam J. Babbs et al. · Pain · 2001 · 266 citations

Pain Medicine, Hypothalamic Peptide Orexin-a, Neuropathic Pain +16

Identification of a novel series of BET family bromodomain inhibitors: Binding mode and profile of I-BET151 (GSK1210151A)

Jonathan T. Seal, Yann Lamotte, Frédéric Donche et al. · Bioorganic & Medicinal Chemistry Letters · 2012 · 207 citations · Full text

Novel Series, Medicine, Chemical Biology +4

Potent antimyeloma activity of the novel bromodomain inhibitors I-BET151 and I-BET762

Aristeidis Chaidos, Valentina S. Caputo, Katerina Gouvedenou et al. · Blood · 2013 · 202 citations

Oral administration of a potent and selective non‐peptidic BACE‐1 inhibitor decreases β‐cleavage of amyloid precursor protein and amyloid‐β production <i>in vivo</i>

Ishrut Hussain, Julie A. Hawkins, David C. Harrison et al. · Journal of Neurochemistry · 2006 · 198 citations

Molecular Pharmacology, Alzheimer's Disease, Biochemistry +13