Adam S. Darwich

Spread of α-synuclein pathology through the brain connectome is modulated by selective vulnerability and predicted by network analysis

Michael X. Henderson, Eli J. Cornblath, Adam S. Darwich et al. · Nature Neuroscience · 2019 · 329 citations

Life Sciences, Neurobiology, Neuroscience +17

Interplay of Metabolism and Transport in Determining Oral Drug Absorption and Gut Wall Metabolism: A Simulation Assessment Using the “Advanced Dissolution, Absorption, Metabolism (ADAM)” Model

Adam S. Darwich, Sibylle Neuhoff, Masoud Jamei et al. · Current Drug Metabolism · 2010 · 182 citations

Pharmacy, Pharmacokinetics, Pharmacology +15

The Pharmacokinetics of the CYP3A Substrate Midazolam in Morbidly Obese Patients Before and One Year After Bariatric Surgery

Margreke J. E. Brill, Anne van Rongen, Eric P. van Dongen et al. · Pharmaceutical Research · 2015 · 69 citations · Full text

Pharmacy, Pharmacokinetics, Pharmacology +13

IMI – Oral biopharmaceutics tools project – Evaluation of bottom-up PBPK prediction success part 2: An introduction to the simulation exercise and overview of results

Alison Margolskee, Adam S. Darwich, Xavier Pépin et al. · European Journal of Pharmaceutical Sciences · 2016 · 67 citations · Full text

Pharmacy, Pharmacokinetics, Pharmacology +16

A mechanistic pharmacokinetic model to assess modified oral drug bioavailability post bariatric surgery in morbidly obese patients: interplay between CYP3A gut wall metabolism, permeability and dissolution

Adam S. Darwich, Devendra Pade, Basil J. Ammori et al. · Journal of Pharmacy and Pharmacology · 2012 · 62 citations · Full text

Pharmacy, Pharmacokinetics, Pharmacology +17