Kia Sepassi

Pharmacological Characterization of 1-(5-Chloro-6-(trifluoromethoxy)-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic Acid (JNJ-42041935), a Potent and Selective Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor

Terrance D. Barrett, Heather L. Palomino, Theresa I. Brondstetter et al. · Molecular Pharmacology · 2011 · 76 citations

Pharmacy, Medicinal Chemistry, Pharmacology +14

A Dipolar Cycloaddition Reaction To Access 6-Methyl-4,5,6,7-tetrahydro-1<i>H</i>-[1,2,3]triazolo[4,5-<i>c</i>]pyridines Enables the Discovery Synthesis and Preclinical Profiling of a P2X7 Antagonist Clinical Candidate

Christa C. Chrovian, Akinola Soyode-Johnson, Alexander A. Peterson et al. · Journal of Medicinal Chemistry · 2017 · 76 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +12

Identification of (<i>R</i>)-(2-Chloro-3-(trifluoromethyl)phenyl)(1-(5-fluoropyridin-2-yl)-4-methyl-6,7-dihydro-1<i>H</i>-imidazo[4,5-<i>c</i>]pyridin-5(4<i>H</i>)-yl)methanone (JNJ 54166060), a Small Molecule Antagonist of the P2X7 receptor

Devin M. Swanson, Brad M. Savall, Kevin J. Coe et al. · Journal of Medicinal Chemistry · 2016 · 36 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13

Solubility prediction in octanol: A technical note

Kia Sepassi, Samuel H. Yalkowsky · AAPS PharmSciTech · 2006 · 32 citations · Full text

Natural Sciences, Chemical Engineering, Chemistry +11

Pre-clinical characterization of aryloxypyridine amides as histamine H3 receptor antagonists: Identification of candidates for clinical development

Michael A. Letavic, Leah Aluisio, John Atack et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 27 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +12