Kevin J. Coe

The Fragmented Mitochondrial Ribosomal RNAs of Plasmodium falciparum

Jean E. Feagin, Maria I. Harrell, Kevin J. Coe et al. · PLoS ONE · 2012 · 146 citations · Full text

Life Sciences, Biology, Molecular Biology +14

A Dipolar Cycloaddition Reaction To Access 6-Methyl-4,5,6,7-tetrahydro-1<i>H</i>-[1,2,3]triazolo[4,5-<i>c</i>]pyridines Enables the Discovery Synthesis and Preclinical Profiling of a P2X7 Antagonist Clinical Candidate

Christa C. Chrovian, Akinola Soyode-Johnson, Alexander A. Peterson et al. · Journal of Medicinal Chemistry · 2017 · 76 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +12

Comparison of the Cytotoxicity of the Nitroaromatic Drug Flutamide to Its Cyano Analogue in the Hepatocyte Cell Line TAMH: Evidence for Complex I Inhibition and Mitochondrial Dysfunction Using Toxicogenomic Screening

Kevin J. Coe, Yankai Jia, Han Kiat Ho et al. · Chemical Research in Toxicology · 2007 · 69 citations · Full text

Pharmacy, Pharmacology, Toxicology +17

4-Methyl-6,7-dihydro-4<i>H</i>-triazolo[4,5-<i>c</i>]pyridine-Based P2X7 Receptor Antagonists: Optimization of Pharmacokinetic Properties Leading to the Identification of a Clinical Candidate

Michael A. Letavic, Brad M. Savall, Brett D. Allison et al. · Journal of Medicinal Chemistry · 2017 · 67 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Comparison of in Vitro Bioactivation of Flutamide and Its Cyano Analogue: Evidence for Reductive Activation by Human NADPH:Cytochrome P450 Reductase

Bo Wen, Kevin J. Coe, Peter Rademacher et al. · Chemical Research in Toxicology · 2008 · 48 citations

Pharmacy, Pharmacology, Toxicology +17