Christa C. Chrovian

Neuropsychopharmacology of JNJ-55308942: evaluation of a clinical candidate targeting P2X7 ion channels in animal models of neuroinflammation and anhedonia

Anindya Bhattacharya, Brian Lord, Jan-Sebastian Grigoleit et al. · Neuropsychopharmacology · 2018 · 75 citations · Full text

Neurophysiology, Medicine, Pharmacology +12

A Dipolar Cycloaddition Reaction To Access 6-Methyl-4,5,6,7-tetrahydro-1<i>H</i>-[1,2,3]triazolo[4,5-<i>c</i>]pyridines Enables the Discovery Synthesis and Preclinical Profiling of a P2X7 Antagonist Clinical Candidate

Christa C. Chrovian, Akinola Soyode-Johnson, Alexander A. Peterson et al. · Journal of Medicinal Chemistry · 2017 · 73 citations · Full text

Total Synthesis of Aigialomycin D:  Surprising Chemoselectivity Dependence on Alkyne Structure in Nickel-Catalyzed Cyclizations

Christa C. Chrovian, Beth Knapp‐Reed, John Montgomery · Organic Letters · 2008 · 55 citations

Surprising Chemoselectivity Dependence, Chemical Engineering, Engineering +14

Surprising Role of Aryl Halides in Nickel-Catalyzed Reductive Aldol Reactions

Christa C. Chrovian, John Montgomery · Organic Letters · 2007 · 38 citations

Cross-coupling Reaction, Engineering, Aryl Iodide Additive +10

Novel methyl substituted 1-(5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanones are P2X7 antagonists

Dale A. Rudolph, Jesús Alcázar, Michael K. Ameriks et al. · Bioorganic & Medicinal Chemistry Letters · 2015 · 32 citations · Full text

Medicinal Chemistry, Medicine, Pharmacological Agent +6