Clonal replacement of tumor-specific T cells following PD-1 blockade

Kathryn E. Yost, Ansuman T. Satpathy, Daniel K. Wells, +13

Nature Medicine

Tumor ImmunologyCancer ImmunosurveillanceMedicineImmunologyTumor Immunity +4

ArchR is a scalable software package for integrative single-cell chromatin accessibility analysis

Jeffrey M. Granja, M. Ryan Corces, Sarah E. Pierce, +4

Nature Genetics

The chromatin accessibility landscape of primary human cancers

M. Ryan Corces, Jeffrey M. Granja, Shadi Shams, +19

Science

Massively parallel single-cell chromatin landscapes of human immune cell development and intratumoral T cell exhaustion

Ansuman T. Satpathy, Jeffrey M. Granja, Kathryn E. Yost, +19

Nature Biotechnology

ChromatinSystems BiologyLymphocyte DevelopmentImmune Cell DevelopmentMedicine +11

c-Jun overexpression in CAR T cells induces exhaustion resistance

Rachel C. Lynn, Evan W. Weber, Elena Sotillo, +16

Nature

PhysiologyAutoimmunityTolerance InductionImmunotherapyMedicine +4

Circular ecDNA promotes accessible chromatin and high oncogene expression

Sihan Wu, Kristen M. Turner, Nam Nguyen, +27

Nature

ChromatinDnaChromatin StructureChromatin RemodelingNatural Sciences +8

Single-cell multiomic analysis identifies regulatory programs in mixed-phenotype acute leukemia

Jeffrey M. Granja, Sandy Klemm, Lisa McGinnis, +10

Nature Biotechnology

BioinformaticsFunctional GenomicsSingle Cell SequencingMedicineMixed-phenotype Acute Leukemia +9

Enhancer connectome in primary human cells identifies target genes of disease-associated DNA elements

Maxwell R. Mumbach, Ansuman T. Satpathy, Evan A. Boyle, +24

Nature Genetics

ChromatinGeneticsGenomic MechanismDisease-associated Dna ElementsGene Characterization +8

Single-cell epigenomic analyses implicate candidate causal variants at inherited risk loci for Alzheimer’s and Parkinson’s diseases

M. Ryan Corces, Anna Shcherbina, Soumya Kundu, +15

Nature Genetics

Genome-wide Association StudyNeurodegenerative DiseasesAlzheimer's DiseaseEpigenetic RegulationMedicine +9

ecDNA hubs drive cooperative intermolecular oncogene expression

King L. Hung, Kathryn E. Yost, Liangqi Xie, +31

Nature

ChromatinEcdna HubsMolecular ResearchNatural SciencesDna Replication +4