Kirsten M. Kahler

Discovery of 7-Methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1<i>H</i>-indol-5-yl)-7<i>H</i>-pyrrolo[2,3-<i>d</i>]pyrimidin-4-amine (GSK2606414), a Potent and Selective First-in-Class Inhibitor of Protein Kinase R (PKR)-like Endoplasmic Reticulum Kinase (PERK)

Jeffrey M. Axten, Jesús R. Medina, Yanhong Feng et al. · Journal of Medicinal Chemistry · 2012 · 619 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13

Discovery of Small Molecule RIP1 Kinase Inhibitors for the Treatment of Pathologies Associated with Necroptosis

Philip A. Harris, Deepak Bandyopadhyay, Scott B. Berger et al. · ACS Medicinal Chemistry Letters · 2013 · 137 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

Discovery of a Potent Boronic Acid Derived Inhibitor of the HCV RNA-Dependent RNA Polymerase

Andrew Maynard, Renae M. Crosby, Byron Ellis et al. · Journal of Medicinal Chemistry · 2013 · 56 citations · Full text

Pharmacy, Infectious Diseases, Medicinal Chemistry +17

Design of <i>N</i> -Benzoxaborole Benzofuran GSK8175—Optimization of Human Pharmacokinetics Inspired by Metabolites of a Failed Clinical HCV Inhibitor

Pek Y. Chong, J. Brad Shotwell, John F. Miller et al. · Journal of Medicinal Chemistry · 2019 · 55 citations · Full text

Pharmacy, Pharmacokinetics, Pharmacology +17