The incretin co-agonist tirzepatide requires GIPR for hormone secretion from human islets

Kimberley El, Jonathan D. Douros, Francis S. Willard, +14

Nature Metabolism

Spatiotemporal GLP-1 and GIP receptor signaling and trafficking/recycling dynamics induced by selected receptor mono- and dual-agonists

Aaron Novikoff, Shannon O’Brien, Miriam Bernecker, +11

Molecular Metabolism

Glucose-dependent insulinotropic polypeptide regulates body weight and food intake via GABAergic neurons in mice

Arkadiusz Liśkiewicz, Ahmed Khalil, Daniela Liśkiewicz, +28

Nature Metabolism

GLP-1-mediated delivery of tesaglitazar improves obesity and glucose metabolism in male mice

Carmelo Quarta, Kerstin Stemmer, Aaron Novikoff, +36

Nature Metabolism

Vps37a regulates hepatic glucose production by controlling glucagon receptor localization to endosomes

Revathi Sekar, Karsten Motzler, Yun Kwon, +22

Cell Metabolism

GIPR agonism and antagonism decrease body weight and food intake via different mechanisms in male mice

Robert M. Gutgesell, Ahmed Khalil, Arkadiusz Liśkiewicz, +21

Nature Metabolism

A GLP-1 analogue optimized for cAMP-biased signaling improves weight loss in obese mice

Jonathan D. Douros, Aaron Novikoff, Barent DuBois, +19

Molecular Metabolism

TRPM7 kinase is required for insulin production and compensatory islet responses during obesity

Noushafarin Khajavi, Andreas Beck, Klea Riçku, +14

JCI Insight

Pharmacological targeting of α3β4 nicotinic receptors improves peripheral insulin sensitivity in mice with diet-induced obesity

Sigrid Jall, Meri De Angelis, Anne‐Marie Lundsgaard, +13

Diabetologia

Loss of GIPR in LEPR cells impairs glucose control by GIP and GIP:GLP-1 co-agonism without affecting body weight and food intake in mice

Seun Akindehin, Arkadiusz Liśkiewicz, Daniela Liśkiewicz, +28

Molecular Metabolism