James A. Southers

Decreasing the Rate of Metabolic Ketone Reduction in the Discovery of a Clinical Acetyl-CoA Carboxylase Inhibitor for the Treatment of Diabetes

David A. Griffith, Daniel W. Kung, William P. Esler et al. · Journal of Medicinal Chemistry · 2014 · 87 citations · Full text

Ketone Carbonyl, Pharmacotherapy, Metabolic Remodeling +17

Synthesis and SAR of 1,2,3,4-tetrahydroisoquinolin-1-ones as novel G-protein-coupled receptor 40 (GPR40) antagonists

Paul S. Humphries, John W. Benbow, Paul D. Bonin et al. · Bioorganic & Medicinal Chemistry Letters · 2009 · 51 citations · Full text

Biochemistry, G Protein-coupled Receptor, Medicine +5

Spirolactam-Based Acetyl-CoA Carboxylase Inhibitors: Toward Improved Metabolic Stability of a Chromanone Lead Structure

David A. Griffith, Robert L. Dow, Kim Huard et al. · Journal of Medicinal Chemistry · 2013 · 47 citations · Full text

Medicinal Chemistry, Chromanone Lead Structure, Bioorganic Chemistry +14

The discovery of novel calcium sensing receptor negative allosteric modulators

Gayatri Balan, Jonathan Bauman, Samit K. Bhattacharya et al. · Bioorganic & Medicinal Chemistry Letters · 2009 · 41 citations · Full text

Signal Transduction, Biochemistry, Functional Selectivity +8

Synthesis of Spiropiperidine Lactam Acetyl-CoA Carboxylase Inhibitors

Kim Huard, Scott W. Bagley, Elnaz Menhaji‐Klotz et al. · The Journal of Organic Chemistry · 2012 · 33 citations

Medicinal Chemistry, Parham-type Cyclization, Biochemistry +12