Decreasing the Rate of Metabolic Ketone Reduction in the Discovery of a Clinical Acetyl-CoA Carboxylase Inhibitor for the Treatment of Diabetes

David A. Griffith, Daniel W. Kung, William P. Esler, +15

Journal of Medicinal Chemistry

Ketone CarbonylPharmacotherapyMetabolic RemodelingInsulin SignalingMetabolic Ketone Reduction +15

Synthesis and SAR of 1,2,3,4-tetrahydroisoquinolin-1-ones as novel G-protein-coupled receptor 40 (GPR40) antagonists

Paul S. Humphries, John W. Benbow, Paul D. Bonin, +12

Bioorganic & Medicinal Chemistry Letters

BiochemistryG Protein-coupled ReceptorMedicineFunctional SelectivityReceptor (Biochemistry) +3

Spirolactam-Based Acetyl-CoA Carboxylase Inhibitors: Toward Improved Metabolic Stability of a Chromanone Lead Structure

David A. Griffith, Robert L. Dow, Kim Huard, +20

Journal of Medicinal Chemistry

Medicinal ChemistryChromanone Lead StructureBioorganic ChemistryPharmaceutical ChemistryBiochemistry +12

The discovery of novel calcium sensing receptor negative allosteric modulators

Gayatri Balan, Jonathan Bauman, Samit K. Bhattacharya, +21

Bioorganic & Medicinal Chemistry Letters

Signal TransductionBiochemistryFunctional SelectivityMedicineG Protein-coupled Receptor +6

Synthesis of Spiropiperidine Lactam Acetyl-CoA Carboxylase Inhibitors

Kim Huard, Scott W. Bagley, Elnaz Menhaji‐Klotz, +12

The Journal of Organic Chemistry

Medicinal ChemistryParham-type CyclizationBiochemistryMedicineNatural Sciences +10

The Synthesis of Methyl-Substituted Spirocyclic Piperidine-Azetidine (2,7-Diazaspiro[3.5]nonane) and Spirocyclic Piperidine-Pyrrolidine (2,8-Diazaspiro[4.5]decane) Ring Systems

Aaron Smith, Shawn Cabral, Daniel W. Kung, +6

The Journal of Organic Chemistry

Spirocyclic Piperidine-pyrrolidineMedicinal ChemistryMethyl-substituted Spirocyclic Piperidine-azetidineHeterocyclicNatural Sciences +12

Discovery of spirocyclic-diamine inhibitors of mammalian acetyl CoA-carboxylase

Daniel W. Kung, David A. Griffith, William P. Esler, +20

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistrySpirocyclic-diamine InhibitorsBiochemistryMedicineNatural Sciences +5

Synthesis of 7-Oxo-dihydrospiro[indazole-5,4′-piperidine] Acetyl-CoA Carboxylase Inhibitors

Scott W. Bagley, James A. Southers, Shawn Cabral, +8

The Journal of Organic Chemistry

Medicinal ChemistryNatural SciencesMedicine1-Substituted SpiroindazolesOrganic Chemistry +7

Identification of novel series of pyrazole and indole-urea based DFG-out PYK2 inhibitors

Samit K. Bhattacharya, Gary E. Aspnes, Scott W. Bagley, +24

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryPharmaceutical ScienceNovel SeriesBiochemistryMedicine +7

Metabolism-Guided Design of Short-Acting Calcium-Sensing Receptor Antagonists

James A. Southers, Jonathan Bauman, David A. Price, +15

ACS Medicinal Chemistry Letters

Medicinal ChemistryPharmacological StudyBiochemistryFunctional SelectivityMedicine +13