Mitofusin 2 (Mfn2) links mitochondrial and endoplasmic reticulum function with insulin signaling and is essential for normal glucose homeostasis

David Sebastián, María Isabel Hernández‐Álvarez, Jessica Segalés, +12

Proceedings of the National Academy of Sciences

MitophagyMitochondrial BiologyMetabolic RemodelingGlucose ToleranceInsulin Signaling +22

STAT3 signaling controls satellite cell expansion and skeletal muscle repair

Matthew Tierney, Tufan Aydogdu, David Sala, +4

Nature Medicine

SclerostinSignal TransductionSignaling PathwayBone Morphogenic ProteinSkeletal Muscle +7

Mfn2 deficiency links age‐related sarcopenia and impaired autophagy to activation of an adaptive mitophagy pathway

David Sebastián, Eleonora Sorianello, Jessica Segalés, +12

The EMBO Journal

Cell AutophagyMitophagyDisease MechanismMedicineAdaptive Mitophagy Pathway +7

Deficient Endoplasmic Reticulum-Mitochondrial Phosphatidylserine Transfer Causes Liver Disease

María Isabel Hernández‐Álvarez, David Sebastián, Sara Vives, +29

Cell

HepatologyMitochondrial FunctionMitochondrial DynamicLiver PhysiologyPathology +6

Denervation-activated STAT3–IL-6 signalling in fibro-adipogenic progenitors promotes myofibres atrophy and fibrosis

Luca Madaro, Magda Passafaro, David Sala, +13

Nature Cell Biology

InflammationFibrosisSignal TransductionImmunologyChronic Inflammation +8

Loss of mitochondrial protease OMA1 alters processing of the GTPase OPA1 and causes obesity and defective thermogenesis in mice

Pedro M. Quirós, Andrew Ramsay, David Sala, +8

The EMBO Journal

ObesityMetabolic SyndromeEnergy HomeostasisGtpase Opa1Mitochondrial Function +10

Autophagy Exacerbates Muscle Wasting in Cancer Cachexia and Impairs Mitochondrial Function

Fabio Penna, Riccardo Ballarò, Paula Martínez-Cristóbal, +7

Journal of Molecular Biology

Cell AutophagyMitophagyCancer CachexiaMitochondrial FunctionPhysiology +9

Autonomous Extracellular Matrix Remodeling Controls a Progressive Adaptation in Muscle Stem Cell Regenerative Capacity during Development

Matthew Tierney, Anastasia Gromova, Francesca Boscolo Sesillo, +4

Cell Reports

Autophagy-regulating TP53INP2 mediates muscle wasting and is repressed in diabetes

David Sala, Saška Ivanova, Natàlia Plana, +14

Journal of Clinical Investigation

MitophagyMuscle HypertrophyAutophagy-regulating Tp53inp2 MediatesSkeletal Muscle MassCellular Physiology +18

The Stat3-Fam3a axis promotes muscle stem cell myogenic lineage progression by inducing mitochondrial respiration

David Sala, Thomas J. Cunningham, Michael J. Stec, +6

Nature Communications