Pushpinder Ferris

Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABAA receptor α1 subtype

Ruth M. McKernan, T.W. Rosahl, David S. Reynolds et al. · Nature Neuroscience · 2000 · 941 citations

Medicine, Neuroscience, Pharmacology +14

The antiepileptic agent gabapentin (Neurontin) possesses anxiolytic-like and antinociceptive actions that are reversed byd-serine

L. Singh, Mark J. Field, Pushpinder Ferris et al. · Psychopharmacology · 1996 · 232 citations

Medicine, Neuroscience, Pharmacology +14

3-Phenyl-6-(2-pyridyl)methyloxy-1,2,4-triazolo[3,4-<i>a</i>]phthalazines and Analogues:  High-Affinity γ-Aminobutyric Acid-A Benzodiazepine Receptor Ligands with α2, α3, and α5-Subtype Binding Selectivity over α1

Robert W. Carling, Kevin W. Moore, Leslie J. Street et al. · Journal of Medicinal Chemistry · 2004 · 135 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

Imidazo[1,2<i>-a</i>]pyrimidines as Functionally Selective and Orally Bioavailable GABA_Aα2/α3 Binding Site Agonists for the Treatment of Anxiety Disorders

Simon Goodacre, Leslie J. Street, David J. Hallett et al. · Journal of Medicinal Chemistry · 2005 · 132 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

7-(1,1-Dimethylethyl)-6-(2-ethyl-2 <i>H</i> -1,2,4- triazol-3-ylmethoxy)-3-(2-fluorophenyl)- 1,2,4-triazolo[4,3- <i>b</i> ]pyridazine:  A Functionally Selective γ-Aminobutyric Acid _A (GABA _A ) α2/α3-Subtype Selective Agonist That Exhibits Potent Anxiolytic Activity but Is Not Sedating in Animal Models

Robert W. Carling, Andrew Madin, Alec Guiblin et al. · Journal of Medicinal Chemistry · 2005 · 54 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +15