Andrew Madin

Enantioselective Reduction of α,β‐Unsaturated Carboxylates with NaBH₄ and Catalytic Amounts of Chiral Cobalt Semicorrin Complexes

Urs Leutenegger, Andrew Madin, Andreas Pfaltz · Angewandte Chemie International Edition in English · 1989 · 151 citations

Asymmetric Catalysis, Chemical Engineering, Biosynthesis +15

Apoptosis in T Cell Acute Lymphoblastic Leukemia Cells after Cell Cycle Arrest Induced by Pharmacological Inhibition of Notch Signaling

Huw D. Lewis, Matthew Leveridge, Peter R. Strack et al. · Chemistry & Biology · 2007 · 148 citations

Hematological Malignancy, Mixed-phenotype Acute Leukemia, Malignant Blood Disorder +10

A small-molecule PI3Kα activator for cardioprotection and neuroregeneration

Grace Q. Gong, Benoît Bilanges, Ben Allsop et al. · Nature · 2023 · 136 citations · Full text

Signal Transduction, Signaling Pathway, Medicine +7

Discovery of 5-{4-[(7-Ethyl-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)methyl]piperazin-1-yl}-<i>N</i>-methylpyridine-2-carboxamide (AZD5305): A PARP1–DNA Trapper with High Selectivity for PARP1 over PARP2 and Other PARPs

Jeffrey W. Johannes, Amber Balazs, Derek Barratt et al. · Journal of Medicinal Chemistry · 2021 · 129 citations · Full text

Use of the Intramolecular Heck Reaction for Forming Congested Quaternary Carbon Stereocenters. Stereocontrolled Total Synthesis of (±)-Gelsemine

Andrew Madin, Christopher J. O’Donnell, Taeboem Oh et al. · Journal of the American Chemical Society · 2005 · 117 citations · Full text

Engineering, Heterocyclic, Heck Reaction Conditions +13