Simon Goodacre

Evidence for a Significant Role of α3-Containing GABA_AReceptors in Mediating the Anxiolytic Effects of Benzodiazepines

Rebecca Dias, Wayne F. A. Sheppard, Rosa Fradley et al. · Journal of Neuroscience · 2005 · 244 citations · Full text

Anesthetic Mechanism, Psychopharmacology, Pharmacotherapy +19

Fluorination of 3-(3-(Piperidin-1-yl)propyl)indoles and 3-(3-(Piperazin-1-yl)propyl)indoles Gives Selective Human 5-HT_1D Receptor Ligands with Improved Pharmacokinetic Profiles

Monique B. van Niel, Ian Collins, Margaret S. Beer et al. · Journal of Medicinal Chemistry · 1999 · 157 citations · Full text

Combinatorial Chemistry, Molecular Pharmacology, Medicinal Chemistry +15

Imidazo[1,2<i>-a</i>]pyrimidines as Functionally Selective and Orally Bioavailable GABA_Aα2/α3 Binding Site Agonists for the Treatment of Anxiety Disorders

Simon Goodacre, Leslie J. Street, David J. Hallett et al. · Journal of Medicinal Chemistry · 2005 · 132 citations · Full text

Psychopharmacology, Pharmacotherapy, Experimental Pharmacology +19

GDC-9545 (Giredestrant): A Potent and Orally Bioavailable Selective Estrogen Receptor Antagonist and Degrader with an Exceptional Preclinical Profile for ER+ Breast Cancer

Jun Liang, Robert A. Blake, Jae H. Chang et al. · Journal of Medicinal Chemistry · 2021 · 130 citations · Full text

8-Fluoroimidazo[1,2-a]pyridine: Synthesis, physicochemical properties and evaluation as a bioisosteric replacement for imidazo[1,2-a]pyrimidine in an allosteric modulator ligand of the GABAA receptor

Alexander C. Humphries, Emanuela Gancia, Myra T. Gilligan et al. · Bioorganic & Medicinal Chemistry Letters · 2006 · 113 citations · Full text

Bioisosteric Replacement, Allosteric Modulator Ligand, Medicinal Chemistry +12