Lucy C.J. Ellis

Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition

Julianty Frost, Carles Galdeano, Pedro Soares et al. · Nature Communications · 2016 · 245 citations · Full text

Life Sciences, Medicinal Chemistry, Molecular Biology +14

Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel–Lindau (VHL) E3 Ubiquitin Ligase: Structure–Activity Relationships Leading to the Chemical Probe (2<i>S</i>,4<i>R</i>)-1-((<i>S</i>)-2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-<i>N</i>-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (VH298)

Pedro Soares, Morgan S. Gadd, Julianty Frost et al. · Journal of Medicinal Chemistry · 2017 · 163 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13

Essential but Not Vulnerable: Indazole Sulfonamides Targeting Inosine Monophosphate Dehydrogenase as Potential Leads against<i>Mycobacterium tuberculosis</i>

Yumi Park, A. Pacitto, Tracy Bayliss et al. · ACS Infectious Diseases · 2016 · 91 citations

Life Sciences, Molecular Biology, Pharmacology +13

2-Mercapto-Quinazolinones as Inhibitors of Type II NADH Dehydrogenase and <i>Mycobacterium tuberculosis</i>: Structure–Activity Relationships, Mechanism of Action and Absorption, Distribution, Metabolism, and Excretion Characterization

Dinakaran Murugesan, Peter C. Ray, Tracy Bayliss et al. · ACS Infectious Diseases · 2018 · 76 citations · Full text

Life Sciences, Biochemistry, Pharmacology +15

ATP-dependent transport of statins by human and rat MRP2/Mrp2

Lucy C.J. Ellis, Gabrielle Hawksworth, Richard Weaver · Toxicology and Applied Pharmacology · 2013 · 74 citations

Life Sciences, Biochemistry, Pharmacology +10