Theresa D’Aquila

Discovery of (<i>S</i>)-6-(3-Cyclopentyl-2-(4-(trifluoromethyl)-1<i>H</i>-imidazol-1-yl)propanamido)nicotinic Acid as a Hepatoselective Glucokinase Activator Clinical Candidate for Treating Type 2 Diabetes Mellitus

Jeffrey A. Pfefferkorn, Angel Guzmán-Pérez, John Litchfield et al. · Journal of Medicinal Chemistry · 2011 · 115 citations · Full text

Life Sciences, Biochemistry, Pharmacology +14

Acyl CoA synthetase 5 (ACSL5) ablation in mice increases energy expenditure and insulin sensitivity and delays fat absorption

Thomas A. Bowman, Kayleigh R. O’Keeffe, Theresa D’Aquila et al. · Molecular Metabolism · 2016 · 104 citations · Full text

Life Sciences, Biochemistry, Physiology +17

Designing glucokinase activators with reduced hypoglycemia risk: discovery of N,N-dimethyl-5-(2-methyl-6-((5-methylpyrazin-2-yl)-carbamoyl)benzofuran-4-yloxy)pyrimidine-2-carboxamide as a clinical candidate for the treatment of type 2 diabetes mellitus

Jeffrey A. Pfefferkorn, Angel Guzmán-Pérez, Peter J. Oates et al. · MedChemComm · 2011 · 68 citations

Pharmacy, Biochemistry, Medicinal Chemistry +12

Characterization of the Proteome of Cytoplasmic Lipid Droplets in Mouse Enterocytes after a Dietary Fat Challenge

Theresa D’Aquila, Devika Sirohi, Jeffrey M. Grabowski et al. · PLoS ONE · 2015 · 55 citations · Full text

Life Sciences, Biochemistry, Nutritional Sciences +17

The design and synthesis of indazole and pyrazolopyridine based glucokinase activators for the treatment of Type 2 diabetes mellitus

Jeffrey A. Pfefferkorn, Meihua Tu, Kevin J. Filipski et al. · Bioorganic & Medicinal Chemistry Letters · 2012 · 44 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +13