Design, Synthesis, and Pharmacological Characterization of 2-(2-Furanyl)thiazolo[5,4-<i>d</i>]pyrimidine-5,7-diamine Derivatives: New Highly Potent A_2AAdenosine Receptor Inverse Agonists with Antinociceptive Activity

Flavia Varano, Daniela Catarzi, Fabrizio Vincenzi, +6

Journal of Medicinal Chemistry

Structural investigations on coumarins leading to chromeno[4,3-c]pyrazol-4-ones and pyrano[4,3-c]pyrazol-4-ones: New scaffolds for the design of the tumor-associated carbonic anhydrase isoforms IX and XII

Alessandro Bonardi, Matteo Falsini, Daniela Catarzi, +7

European Journal of Medicinal Chemistry

Combinatorial ChemistryMedicinal ChemistryBiochemistryNatural SciencesNew Scaffolds +4

Crystal Structure and Subsequent Ligand Design of a Nonriboside Partial Agonist Bound to the Adenosine A_2A Receptor

Tasia Amelia, Jacobus P. D. van Veldhoven, Matteo Falsini, +8

Journal of Medicinal Chemistry

The 1,2,4-Triazolo[4,3-<i>a</i>]pyrazin-3-one as a Versatile Scaffold for the Design of Potent Adenosine Human Receptor Antagonists. Structural Investigations to Target the A_2AReceptor Subtype

Matteo Falsini, Lucia Squarcialupi, Daniela Catarzi, +9

Journal of Medicinal Chemistry

The aminopyridine-3,5-dicarbonitrile core for the design of new non-nucleoside-like agonists of the human adenosine A2B receptor

Marco Betti, Daniela Catarzi, Flavia Varano, +6

European Journal of Medicinal Chemistry

New Non-nucleoside-like AgonistsBiochemistryFunctional SelectivityMedicineReceptor (Biochemistry) +5

3-Hydroxy-1<i>H</i>-quinazoline-2,4-dione as a New Scaffold To Develop Potent and Selective Inhibitors of the Tumor-Associated Carbonic Anhydrases IX and XII

Matteo Falsini, Lucia Squarcialupi, Daniela Catarzi, +9

Journal of Medicinal Chemistry

Structural refinement of pyrazolo[4,3- d ]pyrimidine derivatives to obtain highly potent and selective antagonists for the human A 3 adenosine receptor

Lucia Squarcialupi, Daniela Catarzi, Flavia Varano, +8

European Journal of Medicinal Chemistry

BiochemistryFunctional SelectivityMedicineMechanism Of ActionReceptor (Biochemistry) +8

Modifications on the Amino-3,5-dicyanopyridine Core To Obtain Multifaceted Adenosine Receptor Ligands with Antineuropathic Activity

Marco Betti, Daniela Catarzi, Flavia Varano, +12

Journal of Medicinal Chemistry

Antioxidant-Conjugated 1,2,4-Triazolo[4,3-<i>a</i>]pyrazin-3-one Derivatives: Highly Potent and Selective Human A_2A Adenosine Receptor Antagonists Possessing Protective Efficacy in Neuropathic Pain

Matteo Falsini, Daniela Catarzi, Flavia Varano, +11

Journal of Medicinal Chemistry

Imidazo[1,2-a]pyrazin-8-amine core for the design of new adenosine receptor antagonists: Structural exploration to target the A3 and A2A subtypes

Daniela Poli, Matteo Falsini, Flavia Varano, +11

European Journal of Medicinal Chemistry

BiochemistryFunctional SelectivityMedicineNatural SciencesRational Drug Design +8