Timothy Spicer

A small molecule HIV-1 inhibitor that targets the HIV-1 envelope and inhibits CD4 receptor binding

Pin‐Fang Lin, Wade Blair, Tao Wang et al. · Proceedings of the National Academy of Sciences · 2003 · 360 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +17

Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation

Lars Plate, Christina B. Cooley, John J. Chen et al. · eLife · 2016 · 253 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +13

Discovery of 4-Benzoyl-1-[(4-methoxy-1<i>H</i>- pyrrolo[2,3-<i>b</i>]pyridin-3-yl)oxoacetyl]-2- (<i>R</i>)-methylpiperazine (BMS-378806):  A Novel HIV-1 Attachment Inhibitor That Interferes with CD4-gp120 Interactions

Tao Wang, Zhongxing Zhang, Owen B. Wallace et al. · Journal of Medicinal Chemistry · 2003 · 206 citations

Pharmacy, Medicinal Chemistry, Pharmacology +17

Pharmacologic IRE1/XBP1s activation confers targeted ER proteostasis reprogramming

Julia M. D. Grandjean, Aparajita Madhavan, Lauren Čech et al. · Nature Chemical Biology · 2020 · 184 citations · Full text

Life Sciences, Molecular Biology, Pharmacology +9

Discovery of an enzyme and substrate selective inhibitor of ADAM10 using an exosite-binding glycosylated substrate

Franck Madoux, Daniela Dreymüller, Jean-Phillipe Pettiloud et al. · Scientific Reports · 2016 · 179 citations · Full text

Medicine, Medicinal Chemistry, Oncology +14