Aki Yokomizo

Discovery of N-[(1R,2S,5S)-2-{[(5-chloroindol-2-yl)carbonyl]amino}-5-(dimethylcarbamoyl)cyclohexyl]-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxamide hydrochloride: A novel, potent and orally active direct inhibitor of factor Xa

Tsutomu Nagata, Toshiharu Yoshino, Noriyasu Haginoya et al. · Bioorganic & Medicinal Chemistry · 2008 · 42 citations · Full text

Medicinal Chemistry, Biochemistry, Medicine +11

Design, synthesis, and SAR of cis-1,2-diaminocyclohexane derivatives as potent factor Xa inhibitors. Part I: Exploration of 5–6 fused rings as alternative S1 moieties

Kenji Yoshikawa, Aki Yokomizo, Hiroyuki Naito et al. · Bioorganic & Medicinal Chemistry · 2009 · 31 citations

Medicinal Chemistry, Cis-1,2-diaminocyclohexane Derivatives, Heterocyclic +11

Discovery of a new 2-aminobenzhydrol template for highly potent squalene synthase inhibitors

Masanori Ichikawa, Aki Yokomizo, Masao Itoh et al. · Bioorganic & Medicinal Chemistry · 2011 · 25 citations · Full text

Combinatorial Chemistry, Medicinal Chemistry, Biochemistry +9

Discovery of atrop fixed alkoxy-aminobenzhydrol derivatives: Novel, highly potent and orally efficacious squalene synthase inhibitors

Masanori Ichikawa, Aki Yokomizo, Masao Itoh et al. · Bioorganic & Medicinal Chemistry · 2011 · 22 citations · Full text

Combinatorial Chemistry, Medicinal Chemistry, Biochemistry +8