Laurent Rigoreau

Identification of a highly potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (NU7441) by screening of chromenone libraries

Justin J. J. Leahy, Bernard T. Golding, Roger J. Griffin et al. · Bioorganic & Medicinal Chemistry Letters · 2004 · 407 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +10

Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion

Sarah E. Golding, Elizabeth Rosenberg, Nicholas C.K. Valerie et al. · Molecular Cancer Therapeutics · 2009 · 389 citations · Full text

Medicine, Cancer Biology, Oncology +14

Polθ inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance

Diana Zatreanu, Helen M.R. Robinson, Omar Alkhatib et al. · Nature Communications · 2021 · 350 citations · Full text

Life Sciences, Molecular Biology, Oncology +17

Discovery of Potent Chromen-4-one Inhibitors of the DNA-Dependent Protein Kinase (DNA-PK) Using a Small-Molecule Library Approach

Ian R. Hardcastle, Xiaoling Cockcroft, Nicola J. Curtin et al. · Journal of Medicinal Chemistry · 2005 · 170 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

Selective Benzopyranone and Pyrimido[2,1-<i>a</i>]isoquinolin-4-one Inhibitors of DNA-Dependent Protein Kinase:  Synthesis, Structure−Activity Studies, and Radiosensitization of a Human Tumor Cell Line in Vitro

Roger J. Griffin, Gabriele Fontana, Bernard T. Golding et al. · Journal of Medicinal Chemistry · 2004 · 143 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16