ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

Sebastian Doll, Bettina Proneth, Yulia Y. Tyurina, +18

Nature Chemical Biology

Proteinlipid InteractionBiochemistryNatural SciencesFerroptosis SensitivityLipid Movement +2

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

José Pedro Friedmann Angeli, Manuela Schneider, Bettina Proneth, +26

Nature Cell Biology

GlomerulonephritisUrologyRenal FunctionMedicineRenal Failure +10

FSP1 is a glutathione-independent ferroptosis suppressor

Sebastian Doll, Florêncio Porto Freitas, Ron Shah, +29

Nature

Redox SignalingSignal TransductionBiochemistryMedicineNatural Sciences +5

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

Valerian E. Kagan, Gaowei Mao, Feng Qu, +23

Nature Chemical Biology

Adrenal GlandOxysterolBiochemistryPhysiologyCytoskeleton +7

Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis

Irina Ingold, Carsten Berndt, Sabine Schmitt, +21

Cell

BiochemistrySelenium DeficiencySelenium UtilizationReactive Oxygen SpecieMedicine +4

Glutathione Peroxidase 4 Senses and Translates Oxidative Stress into 12/15-Lipoxygenase Dependent- and AIF-Mediated Cell Death

Alexander Seiler, Manuela Schneider, Heidi Förster, +10

Cell Metabolism

InflammationTranslates Oxidative StressGlutathione Peroxidase 4BiochemistryAif-mediated Cell Death +11

On the Mechanism of Cytoprotection by Ferrostatin-1 and Liproxstatin-1 and the Role of Lipid Peroxidation in Ferroptotic Cell Death

Omkar Zilka, Ron Shah, Bo Li, +3

ACS Central Science

T cell lipid peroxidation induces ferroptosis and prevents immunity to infection

Mai Matsushita, Stefan Freigang, Christoph Schneider, +3

The Journal of Experimental Medicine

Adaptive Immune SystemT-regulatory CellLipid PeroxidationImmunologyImmune Regulation +25

Ultrasmall nanoparticles induce ferroptosis in nutrient-deprived cancer cells and suppress tumour growth

Sung Eun Kim, Li Zhang, Kai Ma, +15

Nature Nanotechnology

NanoparticlesNanomedicineUltrasmall NanoparticlesEngineeringTumour Growth +11

A non-canonical vitamin K cycle is a potent ferroptosis suppressor

Eikan Mishima, Junya Ito, Zijun Wu, +24

Nature