Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes

Jill C. Milne, Philip Lambert, Simon Schenk, +25

Nature

Diabetes ManagementMedicineDiabetesType 2Small Molecule Activators +7

A protein deacetylase SIRT1 is a negative regulator of metalloproteinase‐9

Yuji Nakamaru, Chaitanya Vuppusetty, Hiroo Wada, +11

The FASEB Journal

Inflammatory Lung DiseaseAdvanced Lung DiseaseLung InflammationImmunologyMolecular Biology +16

Crystal Structures of Human SIRT3 Displaying Substrate-induced Conformational Changes

Lei Jin, Wentao Wei, Yaobin Jiang, +10

Journal of Biological Chemistry

Protein ChemistryAldo-keto ReductaseBiochemistryProtein FoldingHuman Sirt3 +11

Biochemical characterization, localization, and tissue distribution of the longer form of mouse SIRT3

Lei Jin, Heidi L. Galonek, Kristine Israelian, +15

Protein Science

Discovery of Imidazo[1,2- <i>b</i> ]thiazole Derivatives as Novel SIRT1 Activators

Chi B. Vu, Jean E. Bemis, Jeremy S. Disch, +13

Journal of Medicinal Chemistry

Discovery of oxazolo[4,5-b]pyridines and related heterocyclic analogs as novel SIRT1 activators

Jean E. Bemis, Chi B. Vu, Roger L. Xie, +12

Bioorganic & Medicinal Chemistry Letters

HeterocyclicMedicineChemistryHeterocycle ChemistryRelated Heterocyclic Analogs +3

Discovery of Aminoquinazolines as Potent, Orally Bioavailable Inhibitors of Lck:  Synthesis, SAR, and in Vivo Anti-Inflammatory Activity

Erin F. DiMauro, John Newcomb, Joseph J. Nunes, +38

Journal of Medicinal Chemistry

Pharmaceutical ScienceImmunologyImmunologic MechanismPharmacotherapyImmunotherapeutics +18

Discovery of 4-amino-5,6-biaryl-furo[2,3-d]pyrimidines as inhibitors of Lck: Development of an expedient and divergent synthetic route and preliminary SAR

Erin F. DiMauro, John Newcomb, Joseph J. Nunes, +16

Bioorganic & Medicinal Chemistry Letters

Combinatorial ChemistryMedicinal ChemistryBiochemistryDivergent Synthetic RoutePreliminary Sar +7

Discovery of novel 2,3-diarylfuro[2,3-b]pyridin-4-amines as potent and selective inhibitors of Lck: Synthesis, SAR, and pharmacokinetic properties

Matthew W. Martin, John Newcomb, Joseph J. Nunes, +13

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryMedicineRational Drug DesignSelective InhibitorsPharmacotherapy +5

Synthesis and Characterization of Fatty Acid Conjugates of Niacin and Salicylic Acid

Chi B. Vu, Jean E. Bemis, Ericka L. Benson, +16

Journal of Medicinal Chemistry

Fatty Acid ConjugatesOxidative StressMolecular PharmacologySterol Regulatory ElementMetabolic Signaling +15