Jeremy S. Disch

Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes

Jill C. Milne, Philip Lambert, Simon Schenk et al. · Nature · 2007 · 1.7K citations · Full text

Medicine, Medicinal Chemistry, Molecular Biology +14

Crystallographic structure of a small molecule SIRT1 activator-enzyme complex

Han Dai, April Case, Thomas V. Riera et al. · Nature Communications · 2015 · 203 citations · Full text

Life Sciences, Medicinal Chemistry, Molecular Biology +17

Discovery of Thieno[3,2-<i>d</i>]pyrimidine-6-carboxamides as Potent Inhibitors of SIRT1, SIRT2, and SIRT3

Jeremy S. Disch, Ghotas Evindar, Cynthia H. Chiu et al. · Journal of Medicinal Chemistry · 2013 · 197 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +11

Discovery of Imidazo[1,2- <i>b</i> ]thiazole Derivatives as Novel SIRT1 Activators

Chi B. Vu, Jean E. Bemis, Jeremy S. Disch et al. · Journal of Medicinal Chemistry · 2009 · 120 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +9

Discovery of oxazolo[4,5-b]pyridines and related heterocyclic analogs as novel SIRT1 activators

Jean E. Bemis, Chi B. Vu, Roger L. Xie et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 90 citations

Pharmacy, Chemistry, Medicinal Chemistry +12