Targeted disruption of inducible nitric oxide synthase protects against obesity-linked insulin resistance in muscle

Mylène Perreault, André Marette

Nature Medicine

Insulin ResistanceMetabolic SyndromeObesityBiochemistryMedicine +8

An engineered <i>E. coli</i> Nissle improves hyperammonemia and survival in mice and shows dose-dependent exposure in healthy humans

Caroline Kurtz, Yves Millet, Marja Puurunen, +12

Science Translational Medicine

Insulin stimulation of glucose uptake in skeletal muscles and adipose tissues in vivo is NO dependent

Denis Roy, Mylène Perreault, André Marette

American Journal of Physiology-Endocrinology and Metabolism

Nos BlockadeSkeletal MusclesGlucose UptakeInsulin SignalingObesity +20

Activation of p38 mitogen-activated protein kinase alpha and beta by insulin and contraction in rat skeletal muscle: potential role in the stimulation of glucose transport.

Romel Somwar, Mylène Perreault, Sonia Kapur, +8

Diabetes

Muscle FunctionP38 MapkCellular PhysiologyInsulin SignalingGlucose Transport +20

The SHP-1 protein tyrosine phosphatase negatively modulates glucose homeostasis

Marie-Julie Dubois, Sébastien Bergeron, Hyo‐Jeong Kim, +10

Nature Medicine

Molecular PhysiologySignal TransductionBiochemistryNatural SciencesPhysiology +7

Targeting Acyl-CoA:Diacylglycerol Acyltransferase 1 (DGAT1) with Small Molecule Inhibitors for the Treatment of Metabolic Diseases

Jingsong Cao, Yingjiang Zhou, Haibing Peng, +13

Journal of Biological Chemistry

Small Molecule InhibitorsMetabolic DiseasesMetabolic RemodelingInsulin SignalingDgat1 Inhibition +16

Normal Food Intake and Body Weight in Mice Lacking the G Protein-Coupled Receptor GPR39

Frédéric Tremblay, Mylène Perreault, Lori D. Klaman, +3

Endocrinology

NutritionGpr39 GeneFood IntakeExperimental NutritionGastrointestinal Peptide Hormone +18

Scaffold-based discovery of indeglitazar, a PPAR pan-active anti-diabetic agent

Dean R. Artis, Jack J. Lin, Chao Zhang, +31

Proceedings of the National Academy of Sciences

Metabolic SyndromeMedicinal ChemistryBiochemistryG Protein-coupled ReceptorMedicine +13

Molecular activation of PPARγ by angiotensin II type 1-receptor antagonists

David V. Erbe, Katherine Gartrell, Yanling Zhang, +6

Vascular Pharmacology

Molecular PharmacologySignal TransductionMolecular PhysiologyG Protein-coupled ReceptorMedicine +9

Resistance to the orexigenic effect of ghrelin in dietary-induced obesity in mice: reversal upon weight loss

Mylène Perreault, N Istrate, L Wang, +3

International Journal of Obesity

ObesityMetabolic SyndromeNutritionGastrointestinal Peptide HormoneAppetite Control +11