Targeted disruption of inducible nitric oxide synthase protects against obesity-linked insulin resistance in muscle

Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance

Gökhan S. Hotamışlıgil, Narinder S. Shargill, Bruce M. Spiegelman · Science · 1993 · 7.5K citations

Medicine, Endocrinology, Molecular Biology +17

Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance.

Peter Arner, J F, Richard L. Atkinson et al. · Journal of Clinical Investigation · 1995 · 3.5K citations · Full text

Life Sciences, Molecular Biology, Physiology +16

IRS-1-Mediated Inhibition of Insulin Receptor Tyrosine Kinase Activity in TNF-α- and Obesity-Induced Insulin Resistance

Gökhan S. Hotamışlıgil, Pascal Peraldi, Adriane I. Budavari et al. · Science · 1996 · 2.6K citations

Life Sciences, Endocrinology, Molecular Biology +17

C-Reactive Protein in Healthy Subjects: Associations With Obesity, Insulin Resistance, and Endothelial Dysfunction

John Yudkin, Coen D.A. Stehouwer, J.J. Emeis et al. · Arteriosclerosis Thrombosis and Vascular Biology · 1999 · 2.5K citations · Full text

Veterinary Medicine, Endocrinology, Immunology +17

Hyperinsulinemia as an Independent Risk Factor for Ischemic Heart Disease

Jean‐Pierre Després, Benoı̂t Lamarche, Pascale Mauriège et al. · New England Journal of Medicine · 1996 · 1.7K citations · Full text

Medicine, Cardiology, Endocrinology +11