PTP1B antisense oligonucleotide lowers PTP1B protein, normalizes blood glucose, and improves insulin sensitivity in diabetic mice

Bradley A. Zinker, Cristina M. Rondinone, James M. Trevillyan, +19

Proceedings of the National Academy of Sciences

Reduction of Protein Tyrosine Phosphatase 1B Increases Insulin-Dependent Signaling in <i>ob/ob</i> Mice

Rebecca J. Gum, Lori L. Gaede, Sandra Koterski, +7

Diabetes

Aminopyridine-Based c-Jun N-Terminal Kinase Inhibitors with Cellular Activity and Minimal Cross-Kinase Activity

Bruce G. Szczepankiewicz, Christi Kosogof, Lissa T.J. Nelson, +23

Journal of Medicinal Chemistry

Little Inhibitory ActivityDrug TargetPharmacotherapyChemical BiologyDrug Resistance +19

Protein Tyrosine Phosphatase 1B Reduction Regulates Adiposity and Expression of Genes Involved in Lipogenesis

Cristina M. Rondinone, James M. Trevillyan, Jill E. Clampit, +10

Diabetes

Discovery and Characterization of Non-ATP Site Inhibitors of the Mitogen Activated Protein (MAP) Kinases

Kenneth M. Comess, Chaohong Sun, Cele Abad‐Zapatero, +27

ACS Chemical Biology

Drug TargetKinase InhibitorsMolecular BiologyNon-atp Site InhibitorsSystems Pharmacology +20

Discovery of Potent, Highly Selective, and Orally Bioavailable Pyridine Carboxamide c-Jun NH₂-Terminal Kinase Inhibitors

Hongyu Zhao, Michael D. Serby, Zhili Xin, +17

Journal of Medicinal Chemistry

Drug TargetPharmacotherapyChemical BiologyInsulin SignalingPharmaceutical Chemistry +17

Discovery of a new class of 4-anilinopyrimidines as potent c-Jun N-terminal kinase inhibitors: Synthesis and SAR studies

Mei Liu, Sanyi Wang, Jill E. Clampit, +8

Bioorganic & Medicinal Chemistry Letters

Combinatorial ChemistryMedicinal ChemistryBiochemistryMedicineNatural Sciences +9

PTP1B antisense-treated mice show regulation of genes involved in lipogenesis in liver and fat

Jeffrey F. Waring, Rita Ciurlionis, Jill E. Clampit, +10

Molecular and Cellular Endocrinology

InflammationMetabolic SyndromeSignal TransductionLiver PhysiologyImmunology +7

PKCθ is a key player in the development of insulin resistance

Deanna L. Haasch, Cathleen E. Berg, Jill E. Clampit, +4

Biochemical and Biophysical Research Communications

Insulin ResistanceMetabolic SyndromeKey PlayerMolecular PhysiologySignal Transduction +10

Developmental Switch from Prolonged Insulin Action to Increased Insulin Sensitivity in Protein Tyrosine Phosphatase 1B-Deficient Hepatocytes

Águeda González‐Rodríguez, Jill E. Clampit, Óscar Escribano, +3

Endocrinology

Immortalized Neonatal HepatocytesInsulin SignalingProlonged Insulin ActionMetabolic SyndromeReceptor Tyrosine Kinase +18