David A. Beebe

Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage

Takeshi Nishikawa, Diane Edelstein, Xue Du et al. · Nature · 2000 · 4.2K citations

Metabolic Syndrome, Biochemistry, Mitochondrial Function +11

X-Ray Crystallographic and Kinetic Studies of Human Sorbitol Dehydrogenase

Thomas Pauly, J.L. Ekstrom, David A. Beebe et al. · Structure · 2003 · 98 citations · Full text

Human Sorbitol Dehydrogenase, Bioanalysis, Alcohol Dehydrogenases +1

Acetyl-CoA Carboxylase Inhibition Improves Multiple Dimensions of NASH Pathogenesis in Model Systems

Trenton T. Ross, Collin Crowley, Kenneth L. Kelly et al. · Cellular and Molecular Gastroenterology and Hepatology · 2020 · 89 citations · Full text

Pyridones as glucokinase activators: Identification of a unique metabolic liability of the 4-sulfonyl-2-pyridone heterocycle

Jeffrey A. Pfefferkorn, Jihong Lou, Martha L. Minich et al. · Bioorganic & Medicinal Chemistry Letters · 2009 · 80 citations · Full text

Unique Metabolic Liability, Biochemistry, Medicine +10

A Highly Selective, Non-Hydantoin, Non-Carboxylic Acid Inhibitor of Aldose Reductase with Potent Oral Activity in Diabetic Rat Models:  6-(5-Chloro-3-methylbenzofuran- 2-sulfonyl)-2-<i>H</i>-pyridazin-3-one

Banavara L. Mylari, Sandra J. Armento, David A. Beebe et al. · Journal of Medicinal Chemistry · 2003 · 68 citations · Full text

Oral Bioavailability, Aldo-keto Reductase, Glycobiology +17