Melanie Katz

Targeted degradation of sense and antisense <i>C9orf72</i> RNA foci as therapy for ALS and frontotemporal degeneration

Clotilde Lagier‐Tourenne, Michael W. Baughn, Frank Rigo et al. · Proceedings of the National Academy of Sciences · 2013 · 557 citations · Full text

Life Sciences, Neurobiology, Neurology +14

Gain of Toxicity from ALS/FTD-Linked Repeat Expansions in C9ORF72 Is Alleviated by Antisense Oligonucleotides Targeting GGGGCC-Containing RNAs

Jie Jiang, Qiang Zhu, Tania F. Gendron et al. · Neuron · 2016 · 540 citations · Full text

Life Sciences, Genetics, Molecular Genetics +15

Feedback modulation of cholesterol metabolism by the lipid-responsive non-coding RNA LeXis

Tamer Sallam, Marius C. Jones, Thomas Gilliland et al. · Nature · 2016 · 214 citations

Life Sciences, Genetics, Molecular Biology +16

Hepatotoxicity of high affinity gapmer antisense oligonucleotides is mediated by RNase H1 dependent promiscuous reduction of very long pre-mRNA transcripts

Sebastien A. Burel, Christopher E. Hart, Patrick Cauntay et al. · Nucleic Acids Research · 2015 · 200 citations · Full text

Life Sciences, Molecular Biology, Toxicology +16

IL-10 Signaling Remodels Adipose Chromatin Architecture to Limit Thermogenesis and Energy Expenditure

Prashant Rajbhandari, Brandon J. Thomas, An‐Chieh Feng et al. · Cell · 2017 · 195 citations · Full text

Life Sciences, Molecular Biology, Physiology +14