R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m6A/MYC/CEBPA Signaling

Rui Su, Lei Dong, Chenying Li, +29

Cell

Tumor BiologyMedicineTumor SuppressorCancer BiologyCell Biology +1

Targeting FTO Suppresses Cancer Stem Cell Maintenance and Immune Evasion

Rui Su, Lei Dong, Yangchan Li, +36

Cancer Cell

Immune EvasionMedicineStem Cell MobilizationImmunologyStem Cell Research +6

Histone H3 trimethylation at lysine 36 guides m6A RNA modification co-transcriptionally

Huilin Huang, Hengyou Weng, Keren Zhou, +39

Nature

Histone ModificationsChromatinTranscriptional RegulationChromatin StructureChromatin Remodeling +12

R-2-hydroxyglutarate attenuates aerobic glycolysis in leukemia by targeting the FTO/m6A/PFKP/LDHB axis

Ying Qing, Lei Dong, Lei Gao, +26

Molecular Cell

BiochemistryMedicineCatabolismMetabolic RemodelingCarbonyl Metabolism +6

METTL16 exerts an m6A-independent function to facilitate translation and tumorigenesis

Rui Su, Lei Dong, Yangchan Li, +29

Nature Cell Biology

Signaling PathwayTranslational BiologyCell RegulationMedicineNatural Sciences +8

QKI shuttles internal m7G-modified transcripts into stress granules and modulates mRNA metabolism

Zhicong Zhao, Ying Qing, Lei Dong, +20

Cell

Internal M7g-modified TranscriptsSignal TransductionProtein ExpressionNatural SciencesProtein Biosynthesis +7

METTL16 drives leukemogenesis and leukemia stem cell self-renewal by reprogramming BCAA metabolism

Li Han, Lei Dong, Keith Leung, +26

Cell stem cell

Hematological MalignancyMedicineMixed-phenotype Acute LeukemiaStem Cell ResearchBcaa Metabolism +6

TET2-mediated mRNA demethylation regulates leukemia stem cell homing and self-renewal

Yangchan Li, Meilin Xue, Xiaolan Deng, +30

Cell stem cell

Lineage PlasticityLeukemia Stem CellDevelopmental BiologyCell RegulationMedicine +8

Signal amplification of electrochemical immunosensor for the detection of human serum IgG using double-codified nanosilica particles as labels

Zhaoyang Zhong, Mengxia Li, Debing Xiang, +4

Biosensors and Bioelectronics

EngineeringMedicineBioanalysisImmunologyHuman Serum Igg +9

Homoharringtonine exhibits potent anti-tumor effect and modulates DNA epigenome in acute myeloid leukemia by targeting SP1/TET1/5hmC

Chenying Li, Lei Dong, Rui Su, +22

Haematologica