A conformational restriction approach to the development of dual inhibitors of acetylcholinesterase and serotonin transporter as potential agents for Alzheimer's disease

Narihiro Toda, Keiko Tago, Shinji Marumoto, +12

Bioorganic & Medicinal Chemistry

Alzheimer's DiseaseBiochemistryDual InhibitorsMedicineNeurotransmitter +10

Design and Synthesis of Dual Inhibitors of Acetylcholinesterase and Serotonin Transporter Targeting Potential Agents for Alzheimer's Disease

Hiroshi Kogen, Narihiro Toda, Keiko Tago, +12

Organic Letters

Neurochemical BiomarkersPharmacotherapyChemical BiologyAche Active SitePharmaceutical Chemistry +18

Pharmacological Characterization of RS-1259, an Orally Active Dual Inhibitor of Acetylcholinesterase and Serotonin Transporter, in Rodents: Possible Treatment of Alzheimer’s Disease

Yasuyuki Abe, Atsushi Aoyagi, Takao Hara, +13

Journal of Pharmacological Sciences

Stereospecific Construction of Contiguous Quaternary and Tertiary Stereocenters by Rearrangement from Indoline‐2‐methanol to 2,2,3‐Trisubstituted Tetrahydroquinoline: Application to an Efficient Total Synthesis of Natural Virantmycin

Mayuko Ori, Narihiro Toda, Kazuko Takami, +2

Angewandte Chemie International Edition

Active TetrahydroquinolineDiversity Oriented SynthesisEngineeringNatural SciencesDiversity-oriented Synthesis +12

Design, synthesis and structure–Activity relationships of dual inhibitors of acetylcholinesterase and serotonin transporter as potential agents for Alzheimer's disease

Narihiro Toda, Keiko Tago, Shinji Marumoto, +12

Bioorganic & Medicinal Chemistry

Molecular PharmacologyNeurodegenerative DiseasesAlzheimer's DiseaseBiochemistryDual Inhibitors +10

Stereospecific synthesis of 2,2,3-trisubstituted tetrahydroquinolines: application to the total syntheses of benzastatin E and natural virantmycin

Mayuko Ori, Narihiro Toda, Kazuko Takami, +2

Tetrahedron

EngineeringOrganic ChemistryStereoselective SynthesisHeterocycle Chemistry2,2,3-Trisubstituted Tetrahydroquinolines +6

Total Synthesis of (+)-Benzastatin E via Diastereoselective Grignard Addition to 2-Acylindoline

Narihiro Toda, Mayuko Ori, Kazuko Takami, +2

Organic Letters

Bioorganic ChemistryUnknown Absolute ConfigurationEngineeringOrganic ChemistryDiastereoselective Grignard Addition +15

Stereoselective Synthesis of 4H-5,6-Dihydro-1,3-thiazines by the Reaction of 3-N-Acylamino Alcohols with Lawesson’s Reagent

Takehiko Nishio, Yukako Konno, Mayuko Ori, +1

European Journal of Organic Chemistry

DerivativesFair YieldsLawesson ’3-N-acylamino AlcoholsOrganic Chemistry +10

Sulfur-containing Heterocycles: Facile Synthesis of 4H-1,3-Thiazines by the Reaction of 3-N-Acylamino Ketones with Lawesson's Reagent

Takehiko Nishio, Mayuko Ori

Heterocycles

HeterocyclicFacile SynthesisOrganic ChemistryChemistry3-N-acylamino Ketones +3

Thionation ofN-(?-Halogenoalkyl)-Substituted Amides withLawesson's Reagent: Facile Synthesis of 4,5-Dihydro-1,3-thiazoles and 5,6-Dihydro-4H-1,3-thiazines

Yasuhiro Kodama, Mayuko Ori, Takehiko Nishio

Helvetica Chimica Acta

HeterocyclicThionation Ofn-4,5-Dihydro-1,3-thiazoles 3Facile SynthesisAmides 1 +8