Rapid, Stable, Chemoselective Labeling of Thiols with Julia–Kocieński‐like Reagents: A Serum‐Stable Alternative to Maleimide‐Based Protein Conjugation

Narihiro Toda, Shigehiro Asano, Carlos F. Barbas

Angewandte Chemie International Edition

Medicinal ChemistryBioorganic ChemistryBiochemistryChemoselective LabelingNew Thiol-click Reaction +12

Organocatalytic Amidation and Esterification of Aldehydes with Activating Reagents by a Cross‐Coupling Strategy

Bin Tan, Narihiro Toda, Carlos F. Barbas

Angewandte Chemie International Edition

Cross-coupling ReactionNovel OrganocatalystsActivating ReagentsEngineeringCross‐coupling Strategy +11

A conformational restriction approach to the development of dual inhibitors of acetylcholinesterase and serotonin transporter as potential agents for Alzheimer's disease

Narihiro Toda, Keiko Tago, Shinji Marumoto, +12

Bioorganic & Medicinal Chemistry

Alzheimer's DiseaseBiochemistryDual InhibitorsMedicineNeurotransmitter +10

Design and Synthesis of Dual Inhibitors of Acetylcholinesterase and Serotonin Transporter Targeting Potential Agents for Alzheimer's Disease

Hiroshi Kogen, Narihiro Toda, Keiko Tago, +12

Organic Letters

Neurochemical BiomarkersPharmacotherapyChemical BiologyAche Active SitePharmaceutical Chemistry +18

Pharmacological Characterization of RS-1259, an Orally Active Dual Inhibitor of Acetylcholinesterase and Serotonin Transporter, in Rodents: Possible Treatment of Alzheimer’s Disease

Yasuyuki Abe, Atsushi Aoyagi, Takao Hara, +13

Journal of Pharmacological Sciences

Stereospecific Construction of Contiguous Quaternary and Tertiary Stereocenters by Rearrangement from Indoline‐2‐methanol to 2,2,3‐Trisubstituted Tetrahydroquinoline: Application to an Efficient Total Synthesis of Natural Virantmycin

Mayuko Ori, Narihiro Toda, Kazuko Takami, +2

Angewandte Chemie International Edition

Active TetrahydroquinolineDiversity Oriented SynthesisEngineeringNatural SciencesDiversity-oriented Synthesis +12

Potent and Orally Bioavailable GPR142 Agonists as Novel Insulin Secretagogues for the Treatment of Type 2 Diabetes

Narihiro Toda, Xiaolin Hao, Yasuyuki Ogawa, +25

ACS Medicinal Chemistry Letters

Insulin SignalingMetabolic SyndromeMolecular PharmacologyInsulin DeliveryHealth Sciences +14

Design, synthesis and structure–Activity relationships of dual inhibitors of acetylcholinesterase and serotonin transporter as potential agents for Alzheimer's disease

Narihiro Toda, Keiko Tago, Shinji Marumoto, +12

Bioorganic & Medicinal Chemistry

Molecular PharmacologyNeurodegenerative DiseasesAlzheimer's DiseaseBiochemistryDual Inhibitors +10

Stereospecific synthesis of 2,2,3-trisubstituted tetrahydroquinolines: application to the total syntheses of benzastatin E and natural virantmycin

Mayuko Ori, Narihiro Toda, Kazuko Takami, +2

Tetrahedron

EngineeringOrganic ChemistryStereoselective SynthesisHeterocycle Chemistry2,2,3-Trisubstituted Tetrahydroquinolines +6

Organocatalytic Amidation and Esterification of Aldehydes with Activating Reagents by a Cross‐Coupling Strategy

Bin Tan, Narihiro Toda, Carlos F. Barbas

Angewandte Chemie